{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T08:11:27Z","timestamp":1697443887174},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T00:00:00Z","timestamp":1329696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Propylthiouracil (PTU), one of the mainstays of antithyroid therapy drugs, can lead to antineutrophil cytoplasmic antibody (ANCA) positivity and skin lesions. PTU\u2010induced ANCA\u2010positive vasculitis is rare and even more rare is erythema nodosum.<\/jats:p><jats:p><jats:bold>Objective\u2002<\/jats:bold> To report a case of a 57\u2010year\u2010old woman with hyperthyroidism who developed myeloperoxidase (MPO)\u2010ANCA erythema nodosum after PTU treatment for 11\u2003months.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Skin biopsy demonstrated septal panniculitis without vasculitis. PTU\u2010induced ANCA\u2010positive erythema nodosum was made.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> With discontinuation of PTU and initiation of thalidomide, skin lesions resolved completely in three\u2003weeks, and after three\u2003months, the titers of MPO\u2010ANCA and perinuclear\u2010ANCA (p\u2010ANCA) had decreased remarkably. At 14\u2010month follow\u2010up, the patient was asymptomatic, but low levels of ANCA titers persisted.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> This report indicated that ANCA positive erythema nodosum could develop following PTU treatment. Thalidomide has been proven to be helpful and averted the adverse effects from systemic corticosteroids and other immunosuppressive drugs in this patient.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2011.05135.x","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T19:49:48Z","timestamp":1329767388000},"page":"345-348","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Propylthiouracil\u2010induced ANCA\u2010positive erythema nodosum treated with thalidomide"],"prefix":"10.1111","volume":"51","author":[{"given":"Pengjie","family":"Wan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranganna Y. P.","family":"Hunasehally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruofei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,20]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2009.01100.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1805"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199615010-00004"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91761-A"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01282.x"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.11.4270"},{"key":"e_1_2_4_8_2","first-page":"282","article-title":"Propylthiouracil\u2010induced cutaneous vasculitis","volume":"35","author":"Yarman S","year":"1997","journal-title":"Int J Clin Pharmacol Ther"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.2.453"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02725.x"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc020104"},{"key":"e_1_2_4_12_2","first-page":"62","article-title":"Erythema nodosum related to propylthiouracil treatment for thyrotoxicosis","volume":"21","author":"Keren G","year":"1985","journal-title":"Isr J Med Sci"},{"key":"e_1_2_4_13_2","first-page":"1112","article-title":"Propylthiouracil induced anti\u2010neutrophil cytoplasmic antibody\u2010associated vasculitis with bone marrow plasmacytosis and granulocytopenia","volume":"122","author":"Ozkok A","year":"2009","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03445.x"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70013-7"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2009.04.002"},{"key":"e_1_2_4_17_2","first-page":"10","article-title":"A fatal case of propylthiouracil\u2010induced ANCA\u2010positive vasculitis","volume":"8","author":"Batchelor N","year":"2006","journal-title":"MedGenMed"},{"key":"e_1_2_4_18_2","first-page":"162","article-title":"Propylthiouracil\u2010induced hypersensitivity syndrome","volume":"48","author":"Aycan Z","year":"2006","journal-title":"Turk J Pediatr"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.7.879"},{"key":"e_1_2_4_20_2","first-page":"475","article-title":"Antineutrophil cytoplasmic antibody (ANCA)\u2010positive vasculitis associated to the use of propylthiouracil. Report of four cases","volume":"134","author":"Hidalgo VS","year":"2006","journal-title":"Rev Med Chil"},{"key":"e_1_2_4_21_2","first-page":"674","article-title":"Anti neutrophil cytoplasmatic antibodies\u2010positive vasculitis as a complication of hyperthyreosis treatment with propylthiouracil","volume":"19","author":"Wisniewski P","year":"2005","journal-title":"Pol Merkur Lekarski"},{"key":"e_1_2_4_22_2","first-page":"296","article-title":"PTU\u2010associated cutaneous vasculitis with ANCA anti\u2010MPO and anti\u2010PR3 antibodies","volume":"61","author":"Jacobs EM","year":"2003","journal-title":"Neth J Med"},{"issue":"4","key":"e_1_2_4_23_2","first-page":"S1295","article-title":"Antineutrophilic cytoplasmic antibody\u2010positive systemic vasculitis associated with propylthiouracil therapy: report of 2 children with Graves\u2019 disease","volume":"85","author":"Poomthavorn P","year":"2002","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_4_24_2","first-page":"404","article-title":"Clinicopathological characteristics of propylthiouracil\u2010induced antineutrophil cytoplasmic antibodies\u2010positive vasculitis and their target antigens: a report of 4 cases and literature review","volume":"41","author":"Xu X","year":"2002","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"e_1_2_4_25_2","first-page":"41","article-title":"Propylthiouracil\u2010induced rapidly progressive glomerulonephritis associated with antineutrophil cytoplasmic autoantibodies","volume":"48","author":"Kudoh Y","year":"1997","journal-title":"Clin Nephrol"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100144275"},{"key":"e_1_2_4_27_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081177"},{"key":"e_1_2_4_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077844"},{"key":"e_1_2_4_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.1999.00346.x"},{"key":"e_1_2_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(05)79191-2"},{"key":"e_1_2_4_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03344152"},{"key":"e_1_2_4_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03186.x"},{"key":"e_1_2_4_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03612.x"},{"key":"e_1_2_4_34_2","first-page":"642","article-title":"Propylthiouracil\u2010induced antineutrophil cytoplasm antibody\u2010positive anaphylactoid purpura\u2010like vasculitis\u2014a case report","volume":"99","author":"Wang LH","year":"2000","journal-title":"J Formos Med Assoc"},{"key":"e_1_2_4_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2007.00361.x"},{"key":"e_1_2_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2010.03.003"},{"key":"e_1_2_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00408-8"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2011.05135.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2011.05135.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T03:49:40Z","timestamp":1697341780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2011.05135.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,20]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1365-4632.2011.05135.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2011.05135.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,20]]},"assertion":[{"value":"2012-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}