{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T19:54:11Z","timestamp":1784318051955,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T00:00:00Z","timestamp":1324339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune thyroiditis (AT) is more prevalent in patients with chronic idiopathic urticaria CIU) than in the general population. Previous small studies without any controlled comparison reported that CIU remits in patients with CIU and AT treated with <jats:sc>l<\/jats:sc>\u2010thyroxine. To determine whether <jats:sc>l<\/jats:sc>\u2010thyroxine treatment can improve the clinical course of CIU in patients with the co\u2010occurrence of AT and CIU. A total of 749 patients with CIU were retrospectively studied. Clinical and laboratory evaluation and classification of chronic urticaria were performed according to the EAACI\/GA(2)LEN\/EDF\/WAO guidelines. After <jats:sc>l<\/jats:sc>\u2010thyroxine treatment for 53\u2003\u00b1\u200319\u2003days, euthyroidism was restored in all subjects. Urticaria activity score (UAS) was evaluated at baseline and after three and six\u2003months. The control group consisted of matched 44 euthyroid subjects with CIU. A total of 44 (5.9%) patients were diagnosed to have hypothyroidism related to AT. Autologous serum skin test (ASST) was found to be positive in 17 (38.6%) of them. There was no statistically significant difference in baseline UAS, between the ASST+ (3.94\u2003\u00b1\u20031.52) and the ASST\u2212 (3.63\u2003\u00b1\u20031.42; <jats:italic>P<\/jats:italic>\u2003=\u20030.27) hypothyroid subjects and the euthyroid CIU controls (3.73\u2003\u00b1\u20031.74). During the <jats:sc>l<\/jats:sc>\u2010thyroxine treatment, a significant reduction of UAS was observed in both hypothyroid ASST+ and ASST\u2212 subjects. However, the mean UAS after three and six\u2003months of <jats:sc>l<\/jats:sc>\u2010thyroxine treatment remained not significantly different from that in control euthyroid subjects with CIU. <jats:sc>l<\/jats:sc>\u2010Thyroxine treatment has no effect on the course of CIU in patients with CIU and AT.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2011.05172.x","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T09:46:39Z","timestamp":1324374399000},"page":"94-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The effect of <scp>l<\/scp>\u2010thyroxine treatment on chronic idiopathic urticaria and autoimmune thyroiditis"],"prefix":"10.1111","volume":"51","author":[{"given":"Eli","family":"Magen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Mishal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1983.01650320010007"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00187.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000076480"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06646.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1605"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(00)00323-4"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70226-1"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90180-2"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02178.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00473.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.116217"},{"key":"e_1_2_5_13_2","first-page":"342","article-title":"Successful treatment of chronic idiopathic urticaria associated with thyroid autoimmunity","volume":"10","author":"Gaig P","year":"2000","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00723.x"},{"key":"e_1_2_5_15_2","first-page":"S51","article-title":"Chronic idiopathic urticaria and thyroid autoimmunity: a second opinion","volume":"107","author":"Lauter CB","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.2500\/108854101778250625"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012288602962"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/archderm.1997.03890440085013","article-title":"The pathogenesis of chronic idiopathic urticaria","volume":"133","author":"Saboe RA","year":"1997","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70189-4"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp011186"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.35"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2011.05172.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2011.05172.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T09:44:36Z","timestamp":1697363076000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2011.05172.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,20]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1365-4632.2011.05172.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2011.05172.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,20]]},"assertion":[{"value":"2011-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}