{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:16:52Z","timestamp":1790975812215,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T00:00:00Z","timestamp":1348099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Mycosis fungoides (MF) and the S\u00e9zary syndrome (SS) are non\u2010Hodgkin's lymphomas that present with cutaneous lesions. S\u00e9zary syndrome is characterized by blood involvement, exfoliative eryrthroderma, lymphadenopathy, pruritus, keratoderma, and immunosuppression. This study was to estimate the prevalence of palmoplantar keratoderma and tinea pedis in S\u00e9zary syndrome and to analyze the effectiveness of anti\u2010fungal treatment.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> We conducted a retrospective review of 1562 prospectively collected patients at the MD Anderson Cancer Center Cutaneous Lymphoma Clinic over sixteen years. All patients\u2019 palms and soles were evaluated for clinical evidence of keratoderma (hyperkeratosis) and for dermatophytosis (tinea pedis or unguum) by examining scales under 10% potassium hydroxide by light microscopy for hyphae.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Of 138 S\u00e9zary syndrome patients (88 men, 50 women, median age at diagnosis 64 years), 85 (61.6%) had palmoplantar keratoderma; 45 of the 85 S\u00e9zary syndrome patients (52.9%) also had coexisting tinea pedis. Only 14 (10.1%) had tinea pedis without keratoderma. Treatment for tinea pedis resulted in microscopy cure of keratoderma in 12 of 45 (26.7%) patients and clinical improvement.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The prevalence of palmoplantar keratoderma in S\u00e9zary syndrome is 61.6%, with co\u2010existing tinea pedis found in 52.9%. Palmoplantar keratoderma with tinea pedis showed clinical improvement with fungicidal therapy suggesting that tinea often contributes to the pathogenesis and severity of S\u00e9zary syndrome\u2010related keratoderma.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2011.05204.x","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T01:55:23Z","timestamp":1348192523000},"page":"1195-1198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence and treatment of palmoplantar keratoderma and tinea pedis in patients with S\u00e9zary syndrome"],"prefix":"10.1111","volume":"51","author":[{"given":"Stephanie J.","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Duvic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2008.07.014"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.7.1298"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.118538"},{"key":"e_1_2_6_5_2","first-page":"1372","article-title":"Cutaneous T\u2010cell lymphomas (including rare subtypes). Current concepts. II","volume":"89","author":"Paulli M","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.03771.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5070\/D33BS957XS","article-title":"Current treatment of cutaneous T\u2010cell lymphoma","volume":"7","author":"Duvic M","year":"2001","journal-title":"Dermatol Online J"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200708010-00001"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1988.tb03213.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480100060031"},{"key":"e_1_2_6_11_2","first-page":"2095","article-title":"Topical treatment of common superficial tinea infections","volume":"65","author":"Weinstein A","year":"2002","journal-title":"Am Fam Physician"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02117-0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90675-1"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.319.7202.79"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.10.1279"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00436320"},{"key":"e_1_2_6_17_2","first-page":"439","article-title":"Investigation of tinea pedis and toenail onychomycosis prevalence in patients with psoriasis","volume":"43","author":"Altunay ZT","year":"2009","journal-title":"Mikrobiyol Bul"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70315-3"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2011.05204.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2011.05204.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:16:48Z","timestamp":1697343408000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2011.05204.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,20]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1365-4632.2011.05204.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2011.05204.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,20]]},"assertion":[{"value":"2012-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}