{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:43:07Z","timestamp":1793727787960,"version":"4.6.1"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T00:00:00Z","timestamp":1350345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Fox\u2013Fordyce disease is a rare chronic papular condition with a very characteristic clinical presentation but a nonspecific histopathology. Its traditionally described histopathologic features have been criticized as variable and indistinct. Recently, a perifollicular infiltrate of histiocytes with foamy cytoplasm has been described as a consistent and reliable diagnostic finding.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> To evaluate the traditional and most recently described histopathologic and immunohistochemical attributes of Fox\u2013Fordyce disease, we performed a computerized search of specimens in two dermatopathologic databases in Puerto Rico from the years 2000\u20132010. An additional specimen was donated by a dermatopathologist from an outside institution. Three cases were evaluated using hematoxylin\u2013eosin\u2010stained sections. The tip of an axillary lipoma excision specimen was used as the control tissue. Periodic acid\u2010Schiff, colloidal iron, and immunoperoxidase staining for CD68 and <jats:italic>c<\/jats:italic>\u2010kit (CD117) were performed in all specimens.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> We were able to verify traditionally described histological features such as infundibulum dilation, hyperkeratosis, plugging, acanthosis, and lymphohistiocytic infiltrate. Infundibular spongiosis was also common. A perifollicular foam cell infiltrate was the most distinct pathologic feature among our cases. The periodic acid\u2010Schiff staining patterns suggested that the foam cell cytoplasm material might be similar in nature to the apocrine gland secretion content.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our results confirmed that a perifollicular foam cell infiltrate is the most distinct histopathologic feature. In addition, findings suggest that the intracytoplasmic foam cell material may be similar in nature to the apocrine gland secretion.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2011.05236.x","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T09:39:41Z","timestamp":1350380381000},"page":"1313-1318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Histopathology attributes of Fox\u2013Fordyce disease"],"prefix":"10.1111","volume":"51","author":[{"given":"Cristina N.","family":"Brau Javier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adisbeth","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,16]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1","article-title":"Two cases of a rare papular disease affecting the axillary region","volume":"20","author":"Fox GH","year":"1902","journal-title":"J Cut Genito-Urinary Dis"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1956.01550010040004"},{"key":"e_1_2_5_4_2","volume-title":"Pathology of the Skin","author":"Mckee PH","year":"2005"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1001\/archderm.144.8.1020","article-title":"Perifollicular xanthomatosis as the hallmark of axillary Fox\u2010Fordyce disease","volume":"144","author":"Bormate AB","year":"2008","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2004.00064.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2004.00108.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200412000-00008"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318197b7fd"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-7310(08)74637-4"},{"key":"e_1_2_5_11_2","volume-title":"Resolving Quandaries in Dermatology, Pathology, and Dermatopathology","author":"Ackerman AB","year":"1995"},{"key":"e_1_2_5_12_2","volume-title":"Histologic Diagnosis of Inflammatory Skin Diseases","author":"Ackerman AB","year":"1997"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1960.01580020054008"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1965.01600090051010"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1976.tb04390.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-7310(04)76825-8"},{"key":"e_1_2_5_17_2","first-page":"531","volume-title":"Dermatology","author":"Miller JL","year":"2008"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2011.05236.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2011.05236.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T05:40:05Z","timestamp":1697348405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2011.05236.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,16]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1365-4632.2011.05236.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2011.05236.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,16]]},"assertion":[{"value":"2012-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}