{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:06:27Z","timestamp":1782979587284,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and objectives\u2002<\/jats:bold> Pyoderma gangrenosum (PG) is a disorder, included in the spectrum of neutrophilic and auto\u2010inflammatory dermatoses, whose clinical aspects and outcome we intend to characterize.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold> In a retrospective study based on files of patients diagnosed during a 10\u2010year period (2000\u20132009), we evaluated demographic data, anatomic locations, number of lesions, clinical variants, associated diseases, treatment regimens, healing time, and recurrence.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 24 patients were included, 19 women and five men (F\/M\u2003=\u20033.8\/1), aged between 17 and 89\u2003years (mean 58.3\u2003\u00b1\u200324.6\u2003years) with a diagnosis of PG. Lesions, single in 15 patients (62.5%) and multiple in nine (37.5%), were localized in the lower limbs in 19 patients (79.2%), upper limbs (4), abdomen (4), face (2) and genital area (1). Clinical variants observed were ulcerative (17 patients), pustular (4), bullous (2) and superficial granulomatous (1). Associated systemic diseases were observed in 18 patients (75%), gastrointestinal in seven patients (29.2%), hematological in seven (25%), autoimmune inflammatory in three (12%), and solid tumors in two (8.3%). Systemic steroids were used in the treatment, either alone in 10 patients (41.7%) or combined with cyclosporine in eight (33.3%). Complete healing was achieved in 20 patients, on average five\u2003months after diagnosis, but lesions recurred one or more times in four patients (16.7%).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> As reported in the literature, PG is a rare disorder, more common in females, frequently associated with systemic disease, which compromises the prognosis.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2011.05451.x","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T04:06:54Z","timestamp":1368677214000},"page":"938-945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Pyoderma gangrenosum \u2013 a review of 24 cases observed over 10\u2003years"],"prefix":"10.1111","volume":"52","author":[{"given":"Neide","family":"Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Manuel","family":"Brites","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Gon\u00e7alo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar","family":"Tellechea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9rido","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1930.01440160053009"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00311.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2010.07580_suppl.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s00431-002-1084-8","article-title":"Pyoderma gangrenosum of the skin and respiratory tract in a 5\u2003year\u2010old girl","volume":"162","author":"Takeuchi K","year":"2003","journal-title":"Eur J Pediatr"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00258.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)10187-8"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1586\/17469872.1.3.391"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.333.7560.181"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2007.07.016"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-196908000-00001"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1997.tb01568.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1985.tb03559.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70080-8"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/archderm.1989.01670130059007","article-title":"Present status of pyoderma gangrenosum","volume":"125","author":"Prystowsky JH","year":"1989","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_16_2","first-page":"2207","volume-title":"Fitzpatrick\u2019s Dermatology in General Medicine","author":"Wolff K","year":"1999"},{"key":"e_1_2_6_17_2","first-page":"415","volume-title":"Pyoderma Gangrenosum: Dermatology","author":"Bolognia JL","year":"2003"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03199.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2010.03.025"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1995.tb00919.x"},{"key":"e_1_2_6_21_2","first-page":"201","article-title":"Pyoderma gangrenosum in association with erythema elevatum diutinum: report of two cases","volume":"49","author":"Planagum\u00e0 M","year":"1992","journal-title":"Cutis"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90428-4"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2005.05022.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5070\/D385M5P6FT","article-title":"Pyoderma gangrenosum \u2013 clinical, laboratory and therapeutic approaches. 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