{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:51:44Z","timestamp":1768287104953,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,8,2]],"date-time":"2012-08-02T00:00:00Z","timestamp":1343865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Saliva contains antimicrobial peptides derived from oral epithelium as well as neutrophils in the innate immune response. The aim of this study was to examine the association between salivary human neutrophil peptide (HNP) 1\u20133 levels originating from neutrophils and oral ulcers in patients with Beh\u00e7et\u2019s disease (BD).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Ninety\u2010five patients with BD (F\/M: 39\/56; mean age: 38.7\u2003\u00b1\u200311.9\u2003years) and 53 healthy controls (HC; F\/M: 23\/30; mean age: 35.2\u2003\u00b1\u200310.1\u2003years) were included in the study. The disease control group (F\/M: 20\/33; mean age: 33.7\u2003\u00b1\u200310.7\u2003years) was comprised of patients with oral infection regarding endodontic infection (<jats:italic>n<\/jats:italic>\u2003=\u200332) and pericoronitis (<jats:italic>n<\/jats:italic>\u2003=\u200321). Salivary HNP 1\u20133 levels of groups were measured in unstimulated samples by ELISA (Hycult, the Netherlands).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A statistically significant increase was found in salivary HNP 1\u20133 levels of patients with BD (2268.28\u2003\u00b1\u20031216.38\u2003\u03bcg\/ml) compared with HC (1836.49\u2003\u00b1\u2003857.76\u2003\u03bcg\/ml), patients with endodontic infection (849.9\u2003\u00b1\u2003376.1\u2003\u03bcg\/ml), and patients with pericoronitis (824.3\u2003\u00b1\u2003284.02\u2003\u03bcg\/ml; <jats:italic>P<\/jats:italic>\u2003=\u20030.024, 0.000 and 0.000, respectively). The ratio of active oral ulcer (100%, <jats:italic>n<\/jats:italic>\u2003=\u200314) was higher in low HNP 1\u20133 levels (\u22641000\u2003\u03bcg\/ml) than the others (66.7%, <jats:italic>n<\/jats:italic>\u2003=\u200354) in active patients with BD (<jats:italic>P<\/jats:italic>\u2003=\u20030.008). Moreover, salivary HNP 1\u20133 levels were significantly lower in patients with endodontic infection and patients with pericoronitis compared with those in the HC group and patients with BD (<jats:italic>P<\/jats:italic>\u2003=\u20030.000).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> A decrease in salivary HNP 1\u20133 levels might be a biological factor for predisposition to oral ulcers in patients with BD and oral infection in healthy patients.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2012.05504.x","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T18:28:54Z","timestamp":1344018534000},"page":"1198-1201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Salivary levels of HNP 1\u20133 are related to oral ulcer activity in Beh\u00e7et\u2019s disease"],"prefix":"10.1111","volume":"52","author":[{"given":"Gonca","family":"Mumcu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hale","family":"Cimilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dcmit","family":"Karacayli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevsun","family":"Inanc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filiz","family":"T\u00fcre\u2010\u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emel","family":"Eksioglu\u2010Demiralp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fclin","family":"Ergun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haner","family":"Direskeneli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.996"},{"key":"e_1_2_6_3_2","first-page":"636","article-title":"Ninth International Conference on Behcet\u2019s Disease, Seoul, Korea, May 27\u201329, 2000","volume":"28","author":"Schirmer M","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.2.115"},{"key":"e_1_2_6_5_2","first-page":"S19","article-title":"Neutrophil activation in Behcet\u2019s disease","volume":"19","author":"Eksioglu\u2010Demiralp E","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_6_2","first-page":"S81","article-title":"Oxidative burst response to monosodium urate crystals in patients with Behcet\u2019s syndrome","volume":"23","author":"Gogus F","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0281-6"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-009-0508-6"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077762"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00832.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-6-S1-S13"},{"key":"e_1_2_6_12_2","first-page":"119","article-title":"Antimicrobial peptides in the oral environment: expression and function in health and disease","volume":"7","author":"Dale BA","year":"2005","journal-title":"Curr Issues Mol Biol"},{"key":"e_1_2_6_13_2","first-page":"1078","article-title":"Criteria for diagnosis of Behcet\u2019s disease. 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