{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T10:52:21Z","timestamp":1785667941094,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T00:00:00Z","timestamp":1365033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome is a rare multisystem paraneoplastic condition associated with plasma cell dyscrasia.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> From our institution\u2019s dysproteinemia database, 107 patients met criteria for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome between January 1, 2000, and October 1, 2009. Medical records were reviewed for documented syndrome features at diagnosis. We assessed prevalence of skin findings and associations between dermatologic and other characteristic disease findings.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Of the 107 patients, 96 (90%) had a recognized cutaneous manifestation. Hyperpigmentation and hemangioma were most common (47%), followed by hypertrichosis (38%). Vascular skin changes \u2013 acrocyanosis (34%), Raynaud phenomenon (20%), hyperemia\/erythema (20%), flushing (16%), or rubor (11%) \u2013 occurred in 62%; white nails, sclerodermoid changes, and clubbing occurred in 30%, 26%, and 6%, respectively. Mean number of skin findings per patient was 2.9 (median, 3.0; range, 0\u20137). Presence of cutaneous manifestation was associated with abnormal pulmonary function tests (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001); immunoglobulin G gammopathy was associated with hyperpigmentation and hypertrichosis. No other significant associations were seen.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The high prevalence of skin findings (90%) shows the value of dermatologic evaluation in diagnosis of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome. Our data indicate new associations between skin findings and other disease characteristics.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2012.05648.x","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T01:37:47Z","timestamp":1365125867000},"page":"1349-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Cutaneous manifestations in patients with POEMS syndrome"],"prefix":"10.1111","volume":"52","author":[{"given":"Rachel Y. 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