{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:48:35Z","timestamp":1792100915831,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T00:00:00Z","timestamp":1374624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pemphigus is a group of autoimmune bullous diseases on which the etiopathogenesis of several viruses has been blamed. Coxsackie viruses (<jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>s) are the causative agents of hand, foot, and mouth disease, and herpangina, which have been strongly associated with several autoimmune diseases. The onset of pemphigus after <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> infection and cephalosporin use has been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To detect the presence of <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> in patients with pemphigus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Reverse transcriptase\u2010polymerase chain reaction analysis for <jats:styled-content style=\"fixed-case\">CV RNA<\/jats:styled-content> sequences and immunohistochemical staining for the <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> and adenovirus receptor expression were performed on patient skin samples. <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IgM<\/jats:styled-content> and \u2010IgG serum levels were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two patients and 40 controls were investigated. Neither the <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> and adenovirus receptor expression nor <jats:styled-content style=\"fixed-case\">CV RNA<\/jats:styled-content> sequences was established in the skin samples of patients. The ratio of <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content> positivity was higher in patients (12.5%) than in the controls (5%; <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our preliminary results indicate that the viral genome of <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> does not become persistent in the skin. Further studies with a larger number of cases are needed to clarify the place of <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>s in the etiopathogenesis of pemphigus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-4632.2012.05699.x","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T19:13:53Z","timestamp":1374693233000},"page":"312-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The investigation of the possible relationship between <scp>C<\/scp>oxsackie viruses and pemphigus"],"prefix":"10.1111","volume":"53","author":[{"given":"Nida","family":"Ka\u00e7ar","sequence":"first","affiliation":[{"name":"Departments of Dermatology, Microbiology, and Pathology Pamukkale University Denizli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nural","family":"Cevahir","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, 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