{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:01:21Z","timestamp":1793293281552,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,17]],"date-time":"2013-02-17T00:00:00Z","timestamp":1361059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidermal permeability alterations induced by ablative fractional resurfacing and low\u2010frequency ultrasound technology may offer drug delivery for the treatment of hypertrophic scars through transepidermal drug delivery (<jats:styled-content style=\"fixed-case\">TED<\/jats:styled-content>). This technology can improve treatment efficacy and minimize side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate clinical response and side effects of <jats:styled-content style=\"fixed-case\">TED<\/jats:styled-content> technology in hypertrophic scars in the body and on the face using ablative fractional radiofrequency (<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>) associated with low\u2010frequency acoustic pressure ultrasound (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four patients with hypertrophic scars were treated with triamcinolone using fractional ablative <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>. The treatment procedure comprised three steps: (i) ablative fractional <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content> for skin perforation; (ii) topical application of triamcinolone acetonide 20\u00a0mg\/ml on the perforated skin; and (iii) acoustic pressure wave <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> applied to enhance triamcinolone penetration into the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete resolution was seen after one session in patients with scars on the nose and mandibular area. The scar on the neck showed complete resolution after four sessions. The scar on the knee showed a marked improvement after four sessions. Mild and homogeneous atrophy was observed in hypertrophic scars on the neck.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ablative fractional <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content> associated with acoustic pressure <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> is a new technology aiming to increase drug delivery into skin. This new method can improve the efficacy of steroids in hypertrophic scar treatment, minimizing the risks of localized atrophy and irregular appearance of the treated lesion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-4632.2012.05704.x","type":"journal-article","created":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T21:48:23Z","timestamp":1361224103000},"page":"367-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Topical delivery of triamcinolone via skin pretreated with ablative radiofrequency: a new method in hypertrophic scar treatment"],"prefix":"10.1111","volume":"52","author":[{"given":"Maria C. A.","family":"Issa","sequence":"first","affiliation":[{"name":"Department of Dermatology Fluminense Federal University Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza E. B. P.","family":"Kassuga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fluminense Federal University Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia S.","family":"Chevrand","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fluminense Federal University Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna T. F.","family":"Pires","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fluminense Federal University Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34406.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000195073.73580.46"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20655"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20577"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06051.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30122.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2010.02.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20860"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01307.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170802524445"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02968592"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.07.022"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20725"},{"key":"e_1_2_6_15_1","unstructured":"OrensteinA Bem\u2010YosefT KostenichG et\u00a0al.Fractional ablative radiofrequency and acoustic wave technology for trans\u2010epidermal delivery: in\u2010vivo rat model study. 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