{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T02:48:19Z","timestamp":1769741299586,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sentinel lymph node biopsy (SLNB) is an important tool for accurate staging of patients with melanoma. There is an ongoing debate whether the procedure provides therapeutic benefits or not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We wanted to analyze 10\u2010year data from an academic teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>During 1999\u20132009, 977 patients with early cutaneous melanoma have been treated. Of these, 419 patients had tumors \u22651\u00a0mm thickness. Patients with head and neck tumors were excluded, leaving 364 patients (202 men and 162 women). <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content> was not performed in 163 patients but was performed in 201 patients. For correction of bias, tumors &gt;4\u00a0mm thickness were excluded from further statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The detection rate of <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> was 94.4%. False negative <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> were observed in 8.9%. Adverse effects occurred in 5.5%. The rate of positive <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content> was 16.4% and lymph node involvement 20%. Patients undergoing <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content> had a lower relapse rate (10.6% vs. 33.3%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The most important finding is an almost 50% lower total death rate and melanoma\u2010related death rate in the <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content> subgroup (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 for both).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sentinel lymph node biopsy is an accurate instrument for melanoma staging to detect occult regional lymph node involvement. Data suggest a positive effect on relapse\u2010free survival. The observation of improved long\u2010term survival needs validation in prospective multicenter trials. 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