{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:02:45Z","timestamp":1791237765977,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:00:00Z","timestamp":1363219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tumour necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>)\u2010\u03b1 inhibitors represent potent new therapies for severe forms of psoriasis, psoriatic arthritis, and several other immune\u2010mediated disorders. Paradoxical worsening or <jats:italic>de novo<\/jats:italic> development of psoriasis has been documented with their use. Palmoplantar pustulosis has been one of the commoner presentations of this unusual side effect. Subcorneal pustular dermatosis (<jats:styled-content style=\"fixed-case\">SPD<\/jats:styled-content>) has some similarity to pustular psoriasis, particularly the acral form of <jats:styled-content style=\"fixed-case\">SPD<\/jats:styled-content>. Thus far there have been no biopsy\u2010proven cases of <jats:styled-content style=\"fixed-case\">SPD<\/jats:styled-content> associated with <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 inhibitor use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe clinical and histopathological features of a pustular skin condition which occurred in a 48\u2010year\u2010old woman with rheumatoid arthritis who had started adalimumab four months prior. The adalimumab had been added to her usual treatment with methotrexate because of incomplete symptom control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Painful and pruritic skin lesions were noted on her palms and soles primarily, with some extension to the limbs and abdomen. Examination revealed relatively non\u2010inflamed pustules with fluid levels, together with sparse crusted papules. Histopathology showed subcorneal pustules more suggestive of <jats:styled-content style=\"fixed-case\">SPD<\/jats:styled-content> than pustular psoriasis. The eruption resolved completely when adalimumab was withdrawn; methotrexate was continued.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Subcorneal pustular dermatosis, in addition to psoriasis vulgaris and pustular psoriasis, may occur in patients treated with <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 inhibitors like adalimumab.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-4632.2012.05707.x","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T19:50:43Z","timestamp":1363290643000},"page":"624-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Palmoplantar subcorneal pustular dermatosis following adalimumab therapy for rheumatoid arthritis"],"prefix":"10.1111","volume":"52","author":[{"given":"Maxwell B.","family":"Sauder","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Ottawa Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Glassman","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Ottawa Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02706.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200809010-00001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23835"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630802441234"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.04.003"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.087288"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.2.223"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.008599"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh437"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22811"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630701691236"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02113.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02344.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2000.560209.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06977.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1001\/archderm.1983.01650330007005","article-title":"Subcorneal pustular dermatosis and pustular psoriasis","volume":"119","author":"Sanchez NP","year":"1983","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb00628.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70290-I"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220086020"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(99)00121-2"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2012.05707.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2012.05707.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T22:08:36Z","timestamp":1697321316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2012.05707.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,14]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/j.1365-4632.2012.05707.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2012.05707.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,14]]},"assertion":[{"value":"2013-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}