{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:06:19Z","timestamp":1784775979663,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,1,20]],"date-time":"2013-01-20T00:00:00Z","timestamp":1358640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>The purpose of this study was to document the clinical profile, etiologies, and outcomes of S<\/jats:styled-content>tevens\u2013J<\/jats:styled-content>ohnson syndrome (SJS<\/jats:styled-content>) and toxic epidermal necrolysis (TEN<\/jats:styled-content>) in hospitals in four sub\u2010S<\/jats:styled-content>aharan A<\/jats:styled-content>frican countries.<\/jats:p><\/jats:sec>Patients and methods<\/jats:bold><\/jats:title>A retrospective study on cases of SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> treated in dermatology departments and\/or intensive care units in four sub\u2010S<\/jats:styled-content>aharan A<\/jats:styled-content>frican countries (B<\/jats:styled-content>enin, B<\/jats:styled-content>urkina F<\/jats:styled-content>aso, C<\/jats:styled-content>entral A<\/jats:styled-content>frican R<\/jats:styled-content>epublic, and T<\/jats:styled-content>ogo) from 2000 to 2010. The study focuses on variables such as age, sex, type of SJS<\/jats:styled-content>\/TEN<\/jats:styled-content>, epidermal detachment of the skin surface, HIV<\/jats:styled-content> status, drug(s) involved, and outcomes (death and sequelae).<\/jats:p><\/jats:sec>Results<\/jats:title>This study identified 177 cases of SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> from 2000 to 2010: 129 with SJS<\/jats:styled-content>; 37 TEN<\/jats:styled-content>; and 11 overlapping SJS<\/jats:styled-content>\/TEN<\/jats:styled-content>. The average age of patients was 32.3\u00a0\u00b1\u00a015.4\u00a0years, and the sex ratio (M<\/jats:styled-content>\/F<\/jats:styled-content>) was 0.6. HIV<\/jats:styled-content> serology was positive in 69 (54.8%) of the 126 patients tested. Antibacterial sulfonamides (38.4%) were the most commonly used drugs followed by nevirapine (19.8%) and tuberculosis drugs (5.6%). We recorded 22 deaths (i.e. six cases of SJS<\/jats:styled-content>, 15 of TEN<\/jats:styled-content>, and one of overlapping SJS<\/jats:styled-content>\/TEN<\/jats:styled-content>). Of the 22 patients who died, 16 were infected with HIV<\/jats:styled-content>; among them, seven had an opportunistic infection (four cases of cerebral toxoplasmosis and three of pulmonary tuberculosis). Twenty\u2010seven cases of sequelae were noted with a large part of eye complications.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study has highlighted: (i) the high proportion of patients infected with HIV<\/jats:styled-content> among patients who had SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> in sub\u2010S<\/jats:styled-content>aharan A<\/jats:styled-content>frica; (ii) the high frequency of antiretroviral drugs as new SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> causes in sub\u2010Saharan Africa; and (iii) the impact of HIV<\/jats:styled-content> infection on morbidity and mortality of these affections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-4632.2012.05743.x","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T03:30:36Z","timestamp":1358739036000},"page":"575-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["S<\/scp>tevens\u2013J<\/scp>ohnson syndrome and toxic epidermal necrolysis in sub\u2010S<\/scp>aharan A<\/scp>frica: a multicentric study in four countries"],"prefix":"10.1111","volume":"52","author":[{"given":"Bayaki","family":"Saka","sequence":"first","affiliation":[{"name":"Department of Dermatology CHU Tokoin University of Lom\u00e9 Lom\u00e9 Togo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatou","family":"Barro\u2010Traor\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Yalgado Ou\u00e9draogo University of Ouagadougou Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix A.","family":"Atadokp\u00e9d\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermatology CNHU Cotonou Faculty of Health and Sciences of Cotonou University of Abomey Calavie Cotonou Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9on","family":"Kobangue","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Bangui University of Bangui Bangui Central African Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal Antoine","family":"Niamba","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Yalgado Ou\u00e9draogo University of Ouagadougou Ouagadougou Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Ad\u00e9gbidi","sequence":"additional","affiliation":[{"name":"Department of Dermatology CNHU Cotonou Faculty of Health and Sciences of Cotonou 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