{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T21:30:38Z","timestamp":1768771838839,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T00:00:00Z","timestamp":1374624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>A study was made of the association between recurrent aphthosis (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>) and iron, ferritin, vitamin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12, and folic acid deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 186 adults were consecutively recruited: 92 subjects with <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> (28 males and 64 females, with a mean age of 41\u00a0years) and 94 controls (20 men and 74 women, with a mean age of 44\u00a0years), and subjected to clinical and hematological evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall frequency of hematinic deficiencies was 14.14% in the <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> group versus 6.39% in the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.086). Patient age and a family history of aphthosis were associated to the presence of <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is still no conclusive evidence relevant to the etiopathogenesis of <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>. Routine hematological screening and tests for serum iron, folic acid, and vitamin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 deficiencies should be assessed in all patients with <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-4632.2012.05751.x","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T18:59:26Z","timestamp":1374692366000},"page":"159-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Hematological study of patients with aphthous stomatitis"],"prefix":"10.1111","volume":"53","author":[{"given":"Pia","family":"Lopez\u2010Jornet","sequence":"first","affiliation":[{"name":"Department of Oral Medicine University of Murcia Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Camacho\u2010Alonso","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine University of Murcia Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nieves","family":"Martos","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine University of Murcia Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80403-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090030401"},{"key":"e_1_2_5_4_1","first-page":"95","article-title":"Recurrent aphthous stomatitis","volume":"31","author":"Ship JA","year":"2000","journal-title":"Quintessence Int"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.07.201"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp054630"},{"key":"e_1_2_5_7_1","first-page":"18","article-title":"Estomatitis aftosa recurrente. 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