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Involvement of the oral cavity may be seen in all variants but is most common with <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>. The latter may signal undiagnosed <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection. Its common association with disseminated disease has potentially important diagnostic and therapeutic implications. Oral <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OKS<\/jats:styled-content>) most often affects the hard and soft palate, gingiva, and dorsal tongue with plaques or tumors of coloration ranging from non\u2010pigmented to brownish\u2010red or violaceous. Its involvement ranges from an incidental finding to proliferative tumor formation that interferes with mastication. <jats:styled-content style=\"fixed-case\">OKS<\/jats:styled-content> needs to be distinguished clinically from other entities, including pyogenic granuloma, hemangioma, bacillary angiomatosis, and gingival enlargement caused by cyclosporine, a drug frequently used in recipients of organ transplantation. <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> may flare as part of the immune reconstitution inflammatory syndrome in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients or develop in the context of iatrogenic immunosuppression. Management, which may depend upon a variety of factors including the clinicopathologic type of <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> and results of staging, ranges from no treatment to local measures such as intralesional vinblastine or systemic administration of cytotoxic chemotherapy for disseminated disease. Modification of immunosuppressive regimens often helps control post\u2010transplant <jats:styled-content style=\"fixed-case\">OKS<\/jats:styled-content> but enhances the risk of graft rejection. Screening donors and recipients of organ transplants for <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>\u20108, with prophylactic treatment if infected as well as institution of sirolimus early after transplantation, are proposed strategies aimed at preventing post\u2010transplant <jats:styled-content style=\"fixed-case\">OKS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2012.05758.x","type":"journal-article","created":{"date-parts":[[2013,5,17]],"date-time":"2013-05-17T07:51:31Z","timestamp":1368777091000},"page":"666-672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Oral Kaposi's sarcoma: a review and update"],"prefix":"10.1111","volume":"52","author":[{"given":"Mahnaz","family":"Fatahzadeh","sequence":"first","affiliation":[{"name":"Oral Medicine New Jersey Dental School Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Dermatology and Pathology New Jersey Medical School Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01830024"},{"key":"e_1_2_9_3_1","first-page":"20","article-title":"HIV\u2010associated Kaposi sarcoma in African children","volume":"65","author":"Feller L","year":"2010","journal-title":"SADJ"},{"key":"e_1_2_9_4_1","first-page":"295","volume-title":"Kaposi Sarcoma: a Model of Oncogenesis","author":"Feller L","year":"2010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20945"},{"key":"e_1_2_9_6_1","first-page":"611","article-title":"Sarcoma (Kaposi)","volume":"18","author":"Feit H","year":"1928","journal-title":"Arch Derm Syphilol"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-34344-8_9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199905150-00007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199560120-00020"},{"key":"e_1_2_9_10_1","first-page":"677","article-title":"HIV associated and non\u2010HIV associated types of Kaposi's sarcoma in an African population in Tanzania. 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