{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:20:25Z","timestamp":1764174025984},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Topical bexarotene 1% gel is currently <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content>\u2010approved for early stage (<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content>) persistent or refractory cutaneous <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>). No uniformly effective therapy exists for follicular mucinosis, although several treatments are routinely used. There are no known reports of topical bexarotene being used in the treatment of idiopathic follicular mucinosis when there is no association with <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>. This article reports the first case of bexarotene gel to successfully treat persistent idiopathic follicular mucinosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This study describes a 34\u2010year\u2010old <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>aucasian male with idiopathic follicular mucinosis. The patient had treatment failure with clobetasol 0.05% ointment and narrow\u2010band <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>. Intralesional injections with triamcinolone 5\u00a0mg\/ml were successful for treating the plaques in the beard area. The patient was treated with bexarotene 1% gel applied twice a day to the persistent plaques on the lower extremities. The patient reported significant improvement in hair growth after only six\u00a0weeks of treatment. The treatment was decreased to once a day due to erythema, and he had complete hair regrowth at 26\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Several treatments have been described in the literature, such as corticosteroids, psoralen plus ultraviolet A (<jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>) light therapy, topical nitrogen mustard, and radiation therapy. Isolated cases have documented the beneficial responses of pimecrolimus, dapsone, indomethacin, minocycline, isotretinoin, hydroxychloroquine and interferons. No single treatment has been shown to be consistently effective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical bexarotene 1% gel should be considered for patients with idiopathic follicular mucinosis resistant to standard treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-4632.2012.05789.x","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T03:39:03Z","timestamp":1377229143000},"page":"838-841","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A case of idiopathic follicular mucinosis treated with bexarotene gel"],"prefix":"10.1111","volume":"53","author":[{"given":"Jennifer","family":"Heyl","sequence":"first","affiliation":[{"name":"Department of Dermatology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darius","family":"Mehregan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wayne State University School of Medicine Detroit MI USA"},{"name":"Pinkus Dermatopathology Laboratories Monroe MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Kado","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05399.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.66921"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1957.01550220027005"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.124604"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70055-4"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60662-4"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02345.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02753.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03454.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.031"},{"key":"e_1_2_5_12_1","first-page":"22","article-title":"Follicular mucinosis successfully treated with isotretinoin","volume":"9","author":"Guerriero C","year":"1999","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09759.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2009.21.3.285"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10227-002-0103-8"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-4632.2012.05789.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-4632.2012.05789.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:12:25Z","timestamp":1696302745000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-4632.2012.05789.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,22]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/j.1365-4632.2012.05789.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-4632.2012.05789.x","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,22]]},"assertion":[{"value":"2013-08-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}