{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:11:55Z","timestamp":1696399915604},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T00:00:00Z","timestamp":1388361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Beh\u00e7et's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) is a multisystemic disorder of unknown etiology characterized by chronic relapsing oral aphthous lesions, genital ulcers, and uveitis. Immunological dysfunction is the most emphasized etiopathogenetic factor. Microchimerism is existence of an allogeneic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> in a living creature. There are variable studies investigating the role of microchimerism on etiopathogenesis of autoimmune diseases. To our knowledge, no report has investigated the relationship between microchimerism and <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. We aimed to investigate the possible role of microchimerism on <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> as an autoimmune disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed the <jats:italic><jats:styled-content style=\"fixed-case\">SRY<\/jats:styled-content><\/jats:italic> gene as an indicator of fetal microchimerism in our patient and healthy control groups. The patients were 105 women with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> over 18\u00a0years old who had applied to multidisciplinary Beh\u00e7et's disease clinic at Mersin University between 2005 and 2011. Patients were divided into two groups: group 1 consisted of 39 patients having a son, and group 2, 15 patients either nulliparous or having a daughter. Controls comprised two groups of women according to whether or not they had a son, i.e., group 3 (<jats:italic>n<\/jats:italic>\u00a0=\u00a051) and group 4 (<jats:italic>n<\/jats:italic>\u00a0=\u00a052), respectively. All patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> fulfilled International Study Group criteria for the diagnosis of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010one of 54 (75.9%) patients and four of 103 (3.9%) controls showed presence of the <jats:italic><jats:styled-content style=\"fixed-case\">SRY<\/jats:styled-content><\/jats:italic> gene. The difference between the patient and control groups was statistically significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As a result of our study, microchimerism may be associated with the etiopathogenesis of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. However, we think there is a need for a larger series of studies to support this hypothesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-4632.2012.05804.x","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T10:00:45Z","timestamp":1388397645000},"page":"832-837","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Microchimerism in <scp>B<\/scp>eh\u00e7et's disease"],"prefix":"10.1111","volume":"53","author":[{"given":"Ruken","family":"Alp","sequence":"first","affiliation":[{"name":"Department of Dermatology Mersin University Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysequl U.","family":"Guney","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mersin University Mersin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umit","family":"Tursen","sequence":"additional","affiliation":[{"name":"Department 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