{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:49:05Z","timestamp":1776426545881,"version":"3.51.2"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,28]],"date-time":"2013-04-28T00:00:00Z","timestamp":1367107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The leishmanin skin test (<jats:styled-content style=\"fixed-case\">LST<\/jats:styled-content>) has been used for clinical diagnosis of leishmaniasis and epidemiological studies of the disease. Thus far, evidence has suggested that <jats:styled-content style=\"fixed-case\">LST<\/jats:styled-content> conversion indicates a degree of protection against leishmaniasis. In this study, we have put this assumption to test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>A total of 273 participants with positive <jats:styled-content style=\"fixed-case\">LST<\/jats:styled-content> living in a hyperendemic area for leishmaniasis were followed for three\u00a0years for any occurrence of cutaneous leishmaniasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two of the 273 participants contracted leishmaniasis during the 3\u2010year follow\u2010up. These new cases included participants who had a previous history of active disease, those who had a history of leishmanization, or those who were suspected of having a history of subclinical infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In this study, the incidence of leishmaniasis in individuals with positive <jats:styled-content style=\"fixed-case\">LST<\/jats:styled-content> was close to the general incidence of the disease in the same hyperendemic area. These results suggest that although <jats:styled-content style=\"fixed-case\">LST<\/jats:styled-content> conversion may be a marker for partial immunity towards leishmaniasis, it may not, however, indicate complete protection against the disease, and consequently there is a need for revision of current vaccine development approaches which are based on rendering vaccinated individuals LST positive.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-4632.2012.05850.x","type":"journal-article","created":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T03:56:44Z","timestamp":1367207804000},"page":"827-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Reevaluating leishmanin skin test as a marker for immunity against cutaneous leishmaniasis"],"prefix":"10.1111","volume":"52","author":[{"given":"Amir","family":"Momeni Boroujeni","sequence":"first","affiliation":[{"name":"Isfahan University of Medical Sciences Faculty of Medicine Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malih","family":"Aminjavaheri","sequence":"additional","affiliation":[{"name":"Aminjavaheri Medical Lab Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahador","family":"Moshtaghian","sequence":"additional","affiliation":[{"name":"Zahedan University of Medical Sciences Zahedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Momeni","sequence":"additional","affiliation":[{"name":"Dalhousie University School of Biomedical Engineering Halifax Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Z","family":"Momeni","sequence":"additional","affiliation":[{"name":"Spadana Dermatology Clinic Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,28]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1","article-title":"Control of the 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