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Specific skin signs related to <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> infection are the exanthem of mononucleosis, which is observed more frequently after ingestion of amoxicillin, and oral hairy leukoplakia, a disease occurring mostly in immunocompromised subjects with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection. Other more uncommon cutaneous disorders that have been associated with <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> infection include virus\u2010related exanthems or diseases such as Gianotti\u2013Crosti syndrome, erythema multiforme, and acute genital ulcers. Other skin manifestations, not correlated to virus infection, such as hydroa vacciniforme and drug\u2010induced hypersensitivity syndrome have also been linked to <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>. The putative involvement of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> in skin diseases is growing similarly to other areas of medicine, where the role of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> infection is being investigated in potentially debilitating inflammatory diseases. The prognosis of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> infection in healthy, immunocompetent individuals is excellent. However, lifelong infection, which is kept in check by the host immune system, determines an unpredictable risk of pathologic unpredictable scenarios. In this review, we describe the spectrum of non\u2010tumoral dermatological manifestations that can follow <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> primary infection or reactivation of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> in childhood.<\/jats:p>","DOI":"10.1111\/j.1365-4632.2012.05855.x","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T05:49:50Z","timestamp":1444715390000},"page":"1177-1184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Epstein\u2013Barr virus and skin manifestations in childhood"],"prefix":"10.1111","volume":"52","author":[{"given":"Vito Di","family":"Lernia","sequence":"first","affiliation":[{"name":"Unit of Dermatology Arcispedale S. 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