{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:31:20Z","timestamp":1791412280844,"version":"4.3.3"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,23]],"date-time":"2013-06-23T00:00:00Z","timestamp":1371945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rituximab has been tried increasingly for the treatment of pemphigus vulgaris (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>). However, there is still no consensus about its dosing regimens, efficacy, and side effects due to insufficient clinical trials. The goal of this study was to evaluate its efficacy in the treatment of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>. This is a case series of patients with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> who received rituximab, four doses of 375\u00a0mg\/m<jats:sup>2<\/jats:sup> intravenously weekly, plus concomitant oral prednisolone. The primary outcomes were the rate of initial clinical improvement and marked clinical improvement; secondary outcomes included prednisolone doses (mg\/d) at baseline, three\u00a0months, six\u00a0months and the last visit, as well as the side effects. Forty out of 45 patients completed the study. The mean follow\u2010up time was 12\u00a0\u00b1\u00a010.69\u00a0months (range of 3\u201346\u00a0months). Following treatment with rituximab, all the analyzed patients with <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> had initial clinical improvement after a mean period of 6.35\u00a0weeks and a marked clinical improvement after a mean of 10.13\u00a0months. The mean prednisolone dose (mg\/d) decreased significantly from a baseline level of 48.75\u00a0\u00b1\u00a025.86 to 26.50\u00a0\u00b1\u00a012.95 at three\u00a0months, 20.70\u00a0\u00b1\u00a017.51 at six\u00a0months, and 15.26\u00a0\u00b1\u00a09.98 at the last visit (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). The encountered side effects following rituximab were lung abscess, sepsis, pneumonia, cavernous sinus thrombosis, skin abscess, deep vein thrombosis, generalized arthralgia, and Stevens\u2013Johnson syndrome. According to our study, rituximab may be an effective adjuvant to prednisolone for the treatment of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>; however, its safety profile remains concerning. (<jats:styled-content style=\"fixed-case\">IRCT<\/jats:styled-content> registration number: <jats:styled-content style=\"fixed-case\">IRCT<\/jats:styled-content>201111022704N2.).<\/jats:p>","DOI":"10.1111\/j.1365-4632.2012.5847.x","type":"journal-article","created":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T01:08:43Z","timestamp":1372036123000},"page":"862-867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Adjuvant rituximab in the treatment of pemphigus vulgaris: a phase <scp>II<\/scp> clinical trial"],"prefix":"10.1111","volume":"52","author":[{"given":"Balighi","family":"Kamran","sequence":"first","affiliation":[{"name":"From the Department of Dermatology Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daneshpazhooh","family":"Maryam","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology Tehran University 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