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The purpose of this experiment was to investigate the behavioral specificity of acamprosate and naltrexone treatment in mice on alcohol drinking elicited in a schedule\u2010induced polydipsia (SIP) task. Food\u2010deprived male C57BL\/6J (B6) mice were divided into three groups assigned to a 5% alcohol SIP, water SIP, or a 1\u2010hour limited access regulatory water drinking task. Injections (intraperitoneal) of acute (0, 50, 100, 200, 400\u2003mg\/kg) and chronic (2\u2003\u00d7\u2003100\u2003mg\/kg, 10\u2003days) acamprosate, or naltrexone (0, 1.0, 2.5, 5.0\u2003mg\/kg) were administered. Behavioral drug specificity was determined by comparing alterations in alcohol or water consumption in SIP with alterations in limited access drinking. Additionally, drug effects on drinking\u2010specific measures (g\/kg consumption and lick efficiency) were compared with those of non\u2010drinking measures (head entries for food and locomotor activity) during SIP. In comparison with saline injections, acute acamprosate (400\u2003mg\/kg) reduced both alcohol and water drinking in both SIP and the regulatory drinking conditions, but had no significant effects on non\u2010drinking measures. Chronic administration of acamprosate reduced both alcohol and water drinking during SIP, but did not significantly affect regulatory drinking or non\u2010drinking measures. Naltrexone (1.0, 2.5, 5.0\u2003mg\/kg) reduced alcohol and water drinking in both paradigms, and at the highest dose, significantly reduced head entries for food. These results indicate that acamprosate (acute and chronic) and naltrexone are relatively non\u2010selective in their effects on alcohol self\u2010administration in this task.<\/jats:p>","DOI":"10.1111\/j.1369-1600.2006.00004.x","type":"journal-article","created":{"date-parts":[[2006,10,23]],"date-time":"2006-10-23T08:59:52Z","timestamp":1161593992000},"page":"55-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["PRECLINICAL STUDY: Schedule\u2010induced alcohol drinking: non\u2010selective effects of acamprosate and 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