{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:09:07Z","timestamp":1790680147468,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T00:00:00Z","timestamp":1150934400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The purpose of the present study was to investigate the efficacy of 2\u2003Hz transcutaneous electrical nerve stimulation (TENS) to reduce cue\u2010induced heroin craving and the corresponding cardiovascular responses. Seventy heroin addicts with at least 1\u2003month of abstinence were enrolled and randomly divided into two groups of 35, to receive single\u2010trial 2\u2003Hz TENS (TENS group) or mock TENS (mock group) during experimental procedure, respectively. They were required to express their degree of craving by visual analog scale before and after the presentation of a video\u2010cue, and after TENS treatment, which lasted for 30\u2003minutes. Heart rate and arterial blood pressure were simultaneously monitored in 56 cases, with 28 in each group. Results show that in mock group, video\u2010cue induced a dramatic increase of craving score, which did not return to baseline in 150\u2003minutes, whereas in the TENS group, 2\u2003Hz TENS treatment produced a significant decrease of craving, reaching baseline in 90\u2003minutes. Video\u2010cue induced a significant increase of heart rate and systolic and diastolic blood pressure, which remained elevated for at least 60\u2003minutes in the mock group; whereas in the TENS group, they returned to baseline immediately after the termination of TENS. These results indicate that the craving induced by a heroin\u2010related cue can be immediately and significantly suppressed, and the cardiovascular activation totally abolished by a single\u2010trial 2\u2003Hz TENS for 30\u2003minutes<\/jats:p>","DOI":"10.1111\/j.1369-1600.2006.00020.x","type":"journal-article","created":{"date-parts":[[2006,10,23]],"date-time":"2006-10-23T09:01:31Z","timestamp":1161594091000},"page":"184-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["CLINICAL STUDY: Suppression of cue\u2010induced heroin craving and cue\u2010reactivity by single\u2010trial transcutaneous electrical nerve stimulation at 2\u2003Hz"],"prefix":"10.1111","volume":"11","author":[{"given":"Fei","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu\u2010Zhen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Sheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,22]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorder","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13556210410001674130"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1999.9433273.x"},{"key":"e_1_2_6_5_1","first-page":"73","article-title":"Cue reactivity and cue reactivity interventions in drug dependence","volume":"137","author":"Childress AR","year":"1993","journal-title":"NIDA Res Monogr"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0740-5472(86)90018-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.95.8s2.2.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(98)00004-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2011738"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.154.3.348"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1316.006"},{"key":"e_1_2_6_12_1","first-page":"105","volume-title":"Handbook of Experimental Pharmacology","author":"Han JS","year":"1993"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)00006-1"},{"key":"e_1_2_6_14_1","first-page":"743","volume-title":"Substance Abuse, a Comprehensive Textbook","author":"Han JS","year":"2005"},{"key":"e_1_2_6_15_1","first-page":"275","article-title":"Reappraisal on the efficacy of naltrexon hydrochloride in preventing reabuse of opiates after detoxification among Chinese subjects","volume":"8","author":"Jiang ZN","year":"1999","journal-title":"Chin J Drug Depend"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2003.tb00552.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1995.90810897.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1993.tb01026.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4603(90)90044-X"},{"key":"e_1_2_6_20_1","first-page":"653","volume-title":"Substance Abuse, a Comprehensive Textbook","author":"Rounsaville BJ","year":"2005"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(98)00065-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.1.1"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(95)02036-5"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200004070-00024"},{"key":"e_1_2_6_25_1","first-page":"241","article-title":"Inhibition by peripheral electric stimulation of reinstatement of morphine\u2010induced place preference in rats and drug\u2010craving in heroin addicts","volume":"25","author":"Wang B","year":"2003","journal-title":"J Peking Univ (Health Sci)"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(97)00098-7"},{"key":"e_1_2_6_27_1","first-page":"30","article-title":"Han\u2019s acupoint nerve stimulator (HANS) for the treatment of opiate withdrawal syndrome","volume":"1","author":"Wu LZ","year":"1995","journal-title":"Chin J Pain Med"},{"key":"e_1_2_6_28_1","first-page":"239","article-title":"Treatment on heroin addicts by four channel Han\u2019s acupoint nerve stimulator (HANS)","volume":"31","author":"Wu LZ","year":"1995","journal-title":"J Beijing Med Univ"},{"key":"e_1_2_6_29_1","first-page":"98","article-title":"Effect of Han\u2019s acupoint nerve stimulator (HANS) on the heart rate of 75 inpatients drug heroin withdrawal","volume":"2","author":"Wu LZ","year":"1996","journal-title":"Chin J Pain Med"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1369-1600.2006.00020.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1369-1600.2006.00020.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T19:55:59Z","timestamp":1696881359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1369-1600.2006.00020.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1369-1600.2006.00020.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1369-1600.2006.00020.x","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"2006-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}