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Chronic alcohol drinking in sP rats results in the development of tolerance to a given effect of alcohol (specifically, motor incoordination) and relapse\u2010like drinking (the alcohol deprivation effect). Conversely, sNP rats avoid alcohol virtually completely; their avoidance for alcohol being resistant even to an environmental manipulation such as long\u2010term exposure to alcohol plus sucrose. sP and sNP rats have been characterized for different phenotypes, possibly associated to their different alcohol preference and consumption. In comparison with sNP rats, alcohol\u2010naive sP rats displayed (1) more anxiety\u2010related behaviors; (2) higher initial sensitivity to the locomotor stimulating and sedative\/hypnotic effects of alcohol; and (3) lower sensitivity to the aversive effects of alcohol. The present paper reviews the data collected to date on alcohol drinking behavior and other alcohol\u2010related behaviors in sP and sNP rats. The behavioral profile of sP rats is also compared with that of other lines of selectively bred alcohol\u2010preferring rats and the heterogeneity resulting from this comparison is discussed in terms of different animal models for the different forms of alcoholism.<\/jats:p>","DOI":"10.1111\/j.1369-1600.2006.00031.x","type":"journal-article","created":{"date-parts":[[2006,10,23]],"date-time":"2006-10-23T09:06:51Z","timestamp":1161594411000},"page":"324-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":142,"title":["REVIEW: Phenotypic characterization of genetically selected Sardinian alcohol\u2010preferring (sP) and \u2010non\u2010preferring (sNP) rats"],"prefix":"10.1111","volume":"11","author":[{"given":"Giancarlo","family":"Colombo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Lobina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro A. 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