{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:52:49Z","timestamp":1791859969335,"version":"4.3.4"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T00:00:00Z","timestamp":1318464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The present study evaluated the involvement of the dorsal hippocampal cannabinoid CB1 receptors in the combined effect of ethanol and nicotine on passive avoidance learning in adult male mice. The results indicated that pre\u2010training administration of ethanol (1\u2003g\/kg, i.p.) impaired memory retrieval. Pre\u2010test administration of ethanol (0.5 and 1\u2003g\/kg, i.p.) or nicotine (0.5 and 0.7\u2003mg\/kg, s.c.) significantly reversed ethanol\u2010induced amnesia, suggesting a functional interaction between ethanol and nicotine. Pre\u2010test microinjection of a selective CB1 receptor agonist, ACPA (3 and 5\u2003ng\/mouse), plus an ineffective dose of ethanol (0.25\u2003g\/kg) or nicotine (0.3\u2003mg\/kg) improved memory retrieval, while ACPA by itself could not reverse ethanol\u2010induced amnesia. Pre\u2010test intra\u2010CA1 microinjection of a selective CB1 receptor antagonist, AM251 (0.5\u20132\u2003ng\/mouse), did not lead to a significant change in ethanol\u2010induced amnesia. However, pre\u2010test intra\u2010CA1 microinjection of AM251 prevented the ethanol (1\u2003g\/kg) or nicotine (0.7\u2003mg\/kg) response on ethanol\u2010induced amnesia. In order to support the involvement of the dorsal hippocampal CB1 receptors in nicotine response, the scheduled mixed treatments of AM251 (0.1\u20131\u2003ng\/mouse), ACPA (5\u2003ng\/mouse) and nicotine (0.3\u2003mg\/kg) were used. The results indicated that AM251 reversed the response of ACPA to the interactive effects of nicotine and ethanol in passive avoidance learning. Furthermore, pre\u2010test intra\u2010CA1 microinjection of the same doses of ACPA or AM251 had no effect on memory retrieval. These findings show that the cannabinoid CB1 receptors of dorsal hippocampus are important in the combined effect of ethanol and nicotine on passive avoidance learning.<\/jats:p>","DOI":"10.1111\/j.1369-1600.2011.00387.x","type":"journal-article","created":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T12:41:34Z","timestamp":1318509694000},"page":"241-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Dorsal hippocampal cannabinoid CB1 receptors mediate the interactive effects of nicotine and ethanol on passive avoidance learning in mice"],"prefix":"10.1111","volume":"18","author":[{"given":"Sakineh","family":"Alijanpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameneh","family":"Rezayof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad\u2010Reza","family":"Zarrindast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20711"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00403-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agh111"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05685.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2003.09.005"},{"key":"e_1_2_9_7_1","first-page":"54","article-title":"Calcium channel antagonists suppress cross\u2010tolerance to the anxiogenic effects of d\u2010amphetamine and nicotine in the mouse elevated plus maze test. 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