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It has been proposed that these effects might be mediated by FD\u2010induced increase in plasma levels of ghrelin, a 28\u2010amino acid orexigenic peptide demonstrated to functionally interact with the mesolimbic dopaminergic system. However, a role for ghrelin has been demonstrated only with psychostimulant drugs and alcohol associated behaviors. We therefore examined the role of ghrelin in ongoing heroin self\u2010administration and FD\u2010induced reinstatement of extinguished heroin seeking. As expected, infusions of ghrelin [0.0, 1.5 and 3.0\u2003\u00b5g\/rat, intracerebroventricular (i.c.v.)] produced increases in breakpoints on a progressive ratio schedule of heroin reinforcement. In contrast, central administration of a ghrelin receptor antagonist, [D\u2010Lys\u20103]\u2010GHRP\u20106 (0.0, or 20.0\u2003\u00b5g\/rat, i.c.v.) had no effect on ongoing heroin self\u2010administration under a fixed\u2010ratio 1 schedule, or on FD\u2010induced reinstatement of heroin seeking. These results suggest that signals mediated through ghrelin receptors play a limited role in FD\u2010induced augmentation of heroin reinforcement and reinstatement of extinguished heroin seeking.<\/jats:p>","DOI":"10.1111\/j.1369-1600.2011.00396.x","type":"journal-article","created":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T12:42:05Z","timestamp":1318509725000},"page":"613-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["A limited role for ghrelin in heroin self\u2010administration and food deprivation\u2010induced reinstatement of heroin seeking in 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