{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:54:59Z","timestamp":1783662899686,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1293,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1111\/j.1369-1600.2011.00431.x","type":"journal-article","created":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T01:31:23Z","timestamp":1329442283000},"page":"836-845","source":"Crossref","is-referenced-by-count":33,"title":["BDNF<i>Val<sup>66<\/sup>Met<\/i>genotype is associated with drug-seeking phenotypes in heroin-dependent individuals: a pilot study"],"prefix":"10.1111","volume":"18","author":[{"given":"Mark K.","family":"Greenwald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caren L.","family":"Steinmiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"\u015aliwerska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Lundahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Burmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,16]]},"reference":[{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0306-4522(95)00207-Y","article-title":"Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine system","volume":"68","author":"Berhow","year":"1995","journal-title":"Neuroscience"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ajmg.b.30231","article-title":"Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers","volume":"139","author":"Beuten","year":"2005","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1385\/NMM:5:1:069","article-title":"Neurotrophic mechanisms in drug addiction","volume":"5","author":"Bolanos","year":"2004","journal-title":"Neuromolecular Med"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.biopsych.2005.09.022","article-title":"BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects","volume":"59","author":"Bueller","year":"2006","journal-title":"Biol Psychiatry"},{"issue":"1","key":"10.1111\/j.1369-1600.2011.00431.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"S310","DOI":"10.1038\/sj.bjp.0707509","article-title":"Role of the brain-derived neurotrophic factor at glutamatergic synapses","volume":"153","author":"Carvalho","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1126\/science.1129663","article-title":"Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior","volume":"314","author":"Chen","year":"2006","journal-title":"Science"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1523\/JNEUROSCI.0348-04.2004","article-title":"Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons","volume":"24","author":"Chen","year":"2004","journal-title":"J Neurosci"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.molbrainres.2005.07.008","article-title":"Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males","volume":"140","author":"Cheng","year":"2005","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10194-009-0136-0","article-title":"Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism","volume":"10","author":"Di Lorenzo","year":"2008","journal-title":"J Headache Pain"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1111\/j.1360-0443.2008.02203.x","article-title":"Genetic approaches to addiction: genes and alcohol","volume":"103","author":"Ducci","year":"2008","journal-title":"Addiction"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","article-title":"The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function","volume":"112","author":"Egan","year":"2003","journal-title":"Cell"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/npp.2008.171","article-title":"GABRA1 and GABRA2 as independent predictors for alcoholism in two populations","volume":"34","author":"Enoch","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s002130000566","article-title":"Second-order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug-seeking behaviour","volume":"153","author":"Everitt","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1001\/archpsyc.64.4.410","article-title":"Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression","volume":"64","author":"Frodl","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0166-2236(03)00065-1","article-title":"It could be habit forming: drugs of abuse and striatal synaptic plasticity","volume":"26","author":"Gerdeman","year":"2003","journal-title":"Trends Neurosci"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0006-8993(02)02505-2","article-title":"Modulation of neurotransmitter release induced by brain-derived neurotrophic factor in rat brain striatal slices in vitro","volume":"941","author":"Goggi","year":"2002","journal-title":"Brain Res"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB20|cit17","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","article-title":"The endophenotype concept in psychiatry: etymology and strategic intentions","volume":"160","author":"Gottesman","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB17|cit18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.drugalcdep.2010.03.020","article-title":"Effects of experimental unemployment, employment and punishment analogs on opioid seeking and consumption in heroin-dependent volunteers","volume":"111","author":"Greenwald","year":"2010","journal-title":"Drug Alcohol Depend"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB18|cit19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.drugalcdep.2006.03.007","article-title":"Behavioral economic analysis of opioid consumption in heroin-dependent individuals: effects of unit price and pre-session drug supply","volume":"85","author":"Greenwald","year":"2006","journal-title":"Drug Alcohol Depend"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB19|cit20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.drugalcdep.2009.04.006","article-title":"Behavioral economic analysis of opioid consumption in heroin-dependent individuals: Effects of alternative reinforcer magnitude and post-session drug supply","volume":"104","author":"Greenwald","year":"2009","journal-title":"Drug Alcohol Depend"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.1523\/JNEUROSCI.23-17-06690.2003","article-title":"Brain-derived neurotrophic factor Val66Met polymorphism affects human memory-related hippocampal activity and predicts memory performance","volume":"23","author":"Hariri","year":"2003","journal-title":"J Neurosci"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.npep.2007.04.007","article-title":"Alterations of BDNF and NT-3 genes expression in the nucleus paragigantocellularis during morphine dependency and withdrawal","volume":"41","author":"Hatami","year":"2007","journal-title":"Neuropeptides"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/alcalc\/agn032","article-title":"Addictions biology: haplotype-based analysis for 130 candidate genes on a single array","volume":"43","author":"Hodgkinson","year":"2008","journal-title":"Alcohol Alcohol"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.pharmtox.010909.105826","article-title":"Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment","volume":"50","author":"Khokhar","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0893-133X(00)00195-0","article-title":"Drug addiction, dysregulation of reward, and allostasis","volume":"24","author":"Koob","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00213-006-0647-1","article-title":"Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smoking","volume":"190","author":"Lang","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00001756-200502080-00022","article-title":"A single cocaine exposure increases BDNF and D3 receptor expression: implications for drug-conditioning","volume":"16","author":"Le Foll","year":"2005","journal-title":"Neuroreport"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB28|cit28","first-page":"403","volume-title":"National Cancer Institute. Phenotypes and Endophenotypes: Foundations for Genetic Studies of Nicotine Use and Dependence","author":"Lerman","year":"2009"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrg2536","article-title":"New insights into the genetics of addiction","volume":"10","author":"Li","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1196\/annals.1403.009","article-title":"Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity","volume":"1122","author":"Lipsky","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0896-6273(03)00538-5","article-title":"Pro-region of neurotrophins: role in synaptic modulation","volume":"39","author":"Lu","year":"2003","journal-title":"Neuron"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1523\/JNEUROSCI.5124-03.2004","article-title":"A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal","volume":"24","author":"Lu","year":"2004","journal-title":"J Neurosci"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/0888-7543(91)90436-I","article-title":"Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations","volume":"10","author":"Maisonpierre","year":"1991","journal-title":"Genomics"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1097\/01.ALC.0000145697.81741.D2","article-title":"Association study of brain-derived neurotrophic factor gene polymorphism and alcoholism","volume":"28","author":"Matsushita","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1469-1809.2010.00578.x","article-title":"Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia","volume":"74","author":"Novak","year":"2010","journal-title":"Ann Hum Genet"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"10700","DOI":"10.1523\/JNEUROSCI.18-24-10700.1998","article-title":"Differential regulation of neurotrophin and trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal","volume":"18","author":"Numan","year":"1998","journal-title":"J Neurosci"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/mp.2009.24","article-title":"Population genetic study of the brain-derived neurotrophic factor (BDNF) gene","volume":"15","author":"Petryshen","year":"2010","journal-title":"Mol Psychiatry"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"10099","DOI":"10.1523\/JNEUROSCI.2680-04.2004","article-title":"The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology","volume":"24","author":"Pezawas","year":"2004","journal-title":"J Neurosci"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.3109\/10826080802487309","article-title":"An economic analysis of income and expenditures in heroin-using research volunteers","volume":"44","author":"Roddy","year":"2009","journal-title":"Subst Use Misuse"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1037\/a0022631","article-title":"Heroin purchasing is income- and price-sensitive","volume":"25","author":"Roddy","year":"2011","journal-title":"Psychol Addict Behav"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuropharm.2008.06.059","article-title":"Neurotrophic factors and structural plasticity in addiction","volume":"56","author":"Russo","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/ajmg.b.30828","article-title":"Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes","volume":"150B","author":"Saccone","year":"2009","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB43|cit43","doi-asserted-by":"crossref","first-page":"11202","DOI":"10.1073\/pnas.93.20.11202","article-title":"Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons","volume":"93","author":"Sklair-Tavron","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB44|cit44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2174\/187152706784111551","article-title":"The dopamine D3 receptor: a therapeutic target for the treatment of neuropsychiatric disorders","volume":"5","author":"Sokoloff","year":"2006","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB45|cit45","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/sj.mp.4001656","article-title":"Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation","volume":"10","author":"Szeszko","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng.571","article-title":"Genome-wide meta-analyses identify multiple loci associated with smoking behavior","volume":"42","author":"The Tobacco and Genetics Consortium","year":"2010","journal-title":"Nat Genet"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB47|cit47","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s002130000493","article-title":"Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies","volume":"151","author":"Vanderschuren","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1126\/science.1168501","article-title":"Ventral tegmental area BDNF induces an opiate-dependent-like reward state in na\u00efve rats","volume":"324","author":"Vargas-Perez","year":"2009","journal-title":"Science"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB49|cit49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1530-0277.2008.00886.x","article-title":"Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence","volume":"33","author":"Wojnar","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB50|cit50","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1098\/rstb.2008.0104","article-title":"Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders","volume":"363","author":"Wong","year":"2008","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1111\/j.1369-1600.2011.00431.x-BIB51|cit51","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1749-6632.2009.05275.x","article-title":"Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment","volume":"1187","author":"Yuferov","year":"2010","journal-title":"Ann N Y Acad Sci"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1369-1600.2011.00431.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1369-1600.2011.00431.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T16:10:31Z","timestamp":1640794231000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1369-1600.2011.00431.x"}},"subtitle":["BDNF and drug-seeking behavior"],"short-title":[],"issued":{"date-parts":[[2012,2,16]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1369-1600.2011.00431.x","relation":{},"ISSN":["1355-6215"],"issn-type":[{"value":"1355-6215","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2,16]]}}}