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Association was conducted for 2\u2003381\u2003914 single\u2010nucleotide polymorphisms (SNPs) using the family\u2010based association test in Merlin followed by gene and pathway enrichment analyses. Although no SNP reached genome\u2010wide significance, six achieved <jats:italic>P<\/jats:italic>\u2010values\u2003&lt;\u20031\u2003\u00d7\u200310<jats:sup>\u22125<\/jats:sup> with variants in three genes (<jats:italic>MT1X<\/jats:italic>, <jats:italic>ATXN1<\/jats:italic> and <jats:italic>VLDLR<\/jats:italic>) implicated in disordered gambling. Secondary case\u2010control analyses found two SNPs on chromosome 9 (rs1106076 and rs12305135 near <jats:italic>VLDLR<\/jats:italic>) and rs10812227 near <jats:italic>FZD10<\/jats:italic> on chromosome 12 to be significantly associated with lifetime Diagnostic and Statistical Manual of Mental Disorders, fourth edition pathological gambling and South Oaks Gambling Screen classified probable pathological gambling status. Furthermore, several addiction\u2010related pathways were enriched for SNPs associated with disordered gambling. Finally, gene\u2010based analysis of 24 candidate genes for dopamine agonist\u2010induced gambling in individuals with Parkinson's disease suggested an enrichment of SNPs associated with disordered gambling. We report the first GWAS of disordered gambling. While further replication is required, the identification of susceptibility loci and biological pathways will be important in characterizing the biological mechanisms that underpin disordered gambling.<\/jats:p>","DOI":"10.1111\/j.1369-1600.2012.00463.x","type":"journal-article","created":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T06:53:14Z","timestamp":1341989594000},"page":"511-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Genome\u2010wide association study of a quantitative disordered gambling trait"],"prefix":"10.1111","volume":"18","author":[{"given":"Penelope A.","family":"Lind","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant W.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela A. 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