{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:06:09Z","timestamp":1771466769387,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T00:00:00Z","timestamp":1341964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Stress is an important factor in the initiation and maintenance of smoking in adolescents. Women are more vulnerable to the development of addiction to smoking and have more difficulty quitting than men. Women also showe enhanced responses to stress. Despite these differences, no work has been done examining the effects of stress on the reinforcing efficacy of self\u2010administered nicotine in adolescent rats, or if there are sex differences. Male and female adolescent <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ong <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>vans rats were trained to self\u2010administer one of three different intravenous doses of nicotine (7.5, 15, 30\u2009\u03bcg\/kg\/infusion) first on fixed ratio, and then on a progressive ratio (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>) schedule beginning on postnatal day 33. The effect of the pharmacological stressor yohimbine (0.3, 0.6\u2009mg\/kg, i.p.) on the reinforcing efficacy of nicotine was then determined using the <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> schedule. Yohimbine stimulated nicotine intake and increased <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> breakpoints and numbers of infusions received in both male and female adolescent rats. The infusion dose of nicotine was positively associated with yohimbine\u2010induced increases in responding. Female rats showed significantly increased breakpoints at yohimbine doses and nicotine infusion doses at which males did not. The effects of the pharmacological stressor, yohimbine on the reinforcing efficacy of nicotine are therefore linked to sex and nicotine infusion dose. Female rats are more sensitive to stress\u2010induced potentiation of nicotine self\u2010administration.<\/jats:p>","DOI":"10.1111\/j.1369-1600.2012.00473.x","type":"journal-article","created":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T11:35:16Z","timestamp":1342006516000},"page":"156-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Sex differences in yohimbine\u2010induced increases in the reinforcing efficacy of nicotine in adolescent rats"],"prefix":"10.1111","volume":"19","author":[{"given":"Sophia","family":"Li","sequence":"first","affiliation":[{"name":"Neurobiology of Alcohol Laboratory Centre for Addiction and Mental Health  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Zou","sequence":"additional","affiliation":[{"name":"Neurobiology of Alcohol Laboratory Centre for Addiction and Mental Health  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Coen","sequence":"additional","affiliation":[{"name":"Neurobiology of Alcohol Laboratory Centre for Addiction and Mental Health  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Funk","sequence":"additional","affiliation":[{"name":"Neurobiology of Alcohol Laboratory Centre for Addiction and Mental Health  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan J.","family":"Shram","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto ON Canada"},{"name":"INC Research Early Stage  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"L\u00ea","sequence":"additional","affiliation":[{"name":"Neurobiology of Alcohol Laboratory Centre for Addiction and Mental Health  Toronto ON Canada"},{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto ON Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2008.01.012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1550-8579(07)80057-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826080802238009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.86.2.214"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050992"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050992"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1700(199910)15:4<215::AID-SMI817>3.0.CO;2-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1440311"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14622200600910793"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(83)90707-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-2152-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301135"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.11.006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(99)00166-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00589894"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genm.2010.09.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00433036"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02895038"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130051153"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000497"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.09.001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2187-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.1998.0433"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301130"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300964"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.12.084"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(03)00006-X"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300391"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-1028-0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-0905-x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(200002)35:2<79::AID-SYN1>3.0.CO;2-X"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05214.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(95)00153-0"},{"key":"e_1_2_8_35_1","volume-title":"Results from the 2007 National Survey on Drug Use and Health:National Findings","author":"SAMHSA","year":"2008"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301454"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.119.6.1477"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(00)00014-2"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420160203"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.04.005"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1607-3"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0846"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(98)00021-5"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2007.09.007"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1369-1600.2012.00473.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1369-1600.2012.00473.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T01:16:39Z","timestamp":1696468599000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1369-1600.2012.00473.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,11]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/j.1369-1600.2012.00473.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1369-1600.2012.00473.x","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,11]]},"assertion":[{"value":"2012-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}