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One of the simplest ways to increase voluntary ethanol intake is to impose temporal limitations on ethanol availability. Escalation of ethanol intake has been observed in both rats and mice under a variety of different schedules of alternating ethanol access and deprivation. Although such effects have been observed in a variety of rat and mouse genotypes, little is known concerning possible genetic correlations between responses to intermittent ethanol access and other ethanol\u2010related phenotypes. In the present study, we examined the effects of intermittent ethanol access in mouse genotypes characterized by divergent responses to ethanol in other domains, including ethanol preference (<jats:styled-content style=\"fixed-case\">C57BL\/6J<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">C3H\/HeJ<\/jats:styled-content>mice), binge\u2010like ethanol drinking (High Drinking in the Dark and<jats:styled-content style=\"fixed-case\">HS\/Npt<\/jats:styled-content>mice) and ethanol withdrawal severity (Withdrawal Seizure\u2010Prone and Withdrawal Seizure\u2010Resistant mice). Although intermittent ethanol access resulted in escalated ethanol intake in all tested genotypes, the robustness of the effect varied across genotypes. On the other hand, we saw no evidence that the effects of intermittent access are correlated with either binge\u2010like drinking or withdrawal severity, and only weak evidence for a genetic correlation with baseline ethanol preference. Thus, these different ethanol\u2010related traits appear to depend on largely unique sets of genetic mediators.<\/jats:p>","DOI":"10.1111\/j.1369-1600.2012.00481.x","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T17:39:45Z","timestamp":1344015585000},"page":"496-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Escalation of intake under intermittent ethanol access in diverse mouse genotypes"],"prefix":"10.1111","volume":"18","author":[{"given":"Alan M.","family":"Rosenwasser","sequence":"first","affiliation":[{"name":"Department of Psychology University of Maine Orono ME USA"},{"name":"School of Biology and Ecology University of Maine Orono ME USA"},{"name":"Graduate School of Biomedical Sciences University of Maine Orono ME USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Fixaris","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Maine Orono ME USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Crabbe","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neuroscience and Portland Alcohol Research Center Oregon Health &amp; 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