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However, the effects of<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ig\u20101<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>agonist on the rewarding effects of abused drugs are not fully understood. Therefore, we examined the effects of selective<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ig\u20101<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>agonists, such as<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>4503 and (+)\u2010pentazocine, on the rewarding effects of abused drugs such as methamphetamine, cocaine and morphine in rats, as measured by the conditioned place preference. Methamphetamine, cocaine and morphine induced a significant place preference.<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>4503, but not (+)\u2010pentazocine, significantly attenuated the abused drug\u2010induced place preference. We recently showed that (+)\u2010pentazocine exerts<jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>50,488<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\u2010like discriminative stimulus effects, which are related to its psychotomimetic\/aversive effects. However,<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>4503 did not generalize to the discriminative stimulus effects of<jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>50,488<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>. These results suggest that<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>4503 inhibits the rewarding effects of abused drugs, and that psychotomimetic\/aversive effects may not play a role in the attenuating effects of<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>4503 on the rewarding effects of abused drugs.<\/jats:p>","DOI":"10.1111\/j.1369-1600.2012.00488.x","type":"journal-article","created":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T09:19:20Z","timestamp":1346404760000},"page":"362-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Inhibitory effects of<scp>SA<\/scp>4503 on the rewarding effects of abused drugs"],"prefix":"10.1111","volume":"19","author":[{"given":"Tomohisa","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Toxicology School of Pharmacy and Pharmaceutical Sciences Hoshi University Tokyo 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