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Thus, identifying neural and genetic correlates of attentional bias is critical for improving interventions. Our previous studies show that the dopamine transporter (<jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\"><jats:italic>SLC6A3<\/jats:italic><\/jats:styled-content> genotype exerts profound effects on limbic responses to <jats:styled-content style=\"fixed-case\">SCs<\/jats:styled-content>. One potential mechanism underlying these effects is greater attentional bias for <jats:styled-content style=\"fixed-case\">SCs<\/jats:styled-content>. Here, we explored associations between attentional bias for <jats:styled-content style=\"fixed-case\">SCs<\/jats:styled-content> and neural responses to <jats:styled-content style=\"fixed-case\">SCs<\/jats:styled-content> among \u2018sated\u2019 smokers genotyped for the <jats:styled-content style=\"fixed-case\"><jats:italic>SLC6A3<\/jats:italic><\/jats:styled-content> polymorphism. Pseudo\u2010continuous arterial spin\u2010labeled perfusion functional magnetic resonance imaging images were acquired during <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> exposure in 35 smokers genotyped for the <jats:styled-content style=\"fixed-case\"><jats:italic>SLC6A3<\/jats:italic><\/jats:styled-content> variable number of tandem repeats polymorphism (<jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u200916, 9\u2010repeats; <jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u200919, 10\/10\u2010repeats). Participants completed a visual dot\u2010probe attentional bias task, which contained pictures of smoking and non\u2010smoking pictures, to examine whether genetic variation in <jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content> influences attentional bias and to investigate relationships between attentional bias and neural responses to <jats:styled-content style=\"fixed-case\">SCs<\/jats:styled-content>. Although attentional bias to smoking pictures was not significantly different between 9\u2010repeats and 10\/10\u2010repeats, 9\u2010repeats showed a positive correlation between attentional bias and increased <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>\u2010induced brain activity in the amygdala, whereas 10\/10\u2010repeats showed an inverse correlation in the medial orbitofrontal cortex (<jats:styled-content style=\"fixed-case\">mOFC<\/jats:styled-content>). In group comparisons, 9\u2010repeats exhibited positive correlations between attentional bias and <jats:styled-content style=\"fixed-case\">SCs<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">mOFC<\/jats:styled-content> and amygdala, relative to 10\/10\u2010repeats. Findings suggest that genetic variation in the <jats:styled-content style=\"fixed-case\">DAT<\/jats:styled-content> gene influences brain responses associated with attentional bias; thus, providing additional support for a <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>\u2010vulnerable endophenotype.<\/jats:p>","DOI":"10.1111\/j.1369-1600.2012.00507.x","type":"journal-article","created":{"date-parts":[[2012,10,12]],"date-time":"2012-10-12T11:48:55Z","timestamp":1350042535000},"page":"294-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Neural correlates of attentional bias for smoking cues: modulation by variance in the dopamine transporter gene"],"prefix":"10.1111","volume":"19","author":[{"given":"Reagan R.","family":"Wetherill","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Pennsylvania  Philadelphia PA 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