{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:50:47Z","timestamp":1763704247865},"reference-count":25,"publisher":"Wiley","issue":"s5","license":[{"start":{"date-parts":[[2004,5,18]],"date-time":"2004-05-18T00:00:00Z","timestamp":1084838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Brain tumors are the second most common malignancy in children and the most common solid tumor. The majority of children are treated with surgery alone or in combination with radiation and\/or chemotherapy. Recently investigators have used high dose chemotherapy with autologous stem cell rescue (ASCR) in patients with malignant brain tumors. This approach has been most successful in chemosensitive tumors including medulloblastoma, supratentorial primitive neuroectodermal tumors (SPNET) and central nervous system germ cell tumors (CNS GCT). In addition, the use of high dose chemotherapy has enabled the reduction and in many cases elimination of radiation therapy to very young children. To date there have been no prospective randomized studies comparing high dose chemotherapy and ASCR with conventional therapy. Radiation therapy is often not an option for patients with recurrent disease and conventional dose chemotherapy rarely if ever results in long\u2010term survival. Unfortunately, the majority of studies using conventional therapy in order to delay irradiation in young children newly diagnosed with malignant brain tumors have been unsuccessful. Although the numbers are small, preliminary data suggest that not only is survival but also quality of life is superior with the use of high dose chemotherapy. Future studies will most likely include the use of new agents as part of the cytoreduction. In addition, through the use of peripheral blood stem cells and improvements in supportive care, multiple courses of high dose chemotherapy can be administered. High dose chemotherapy with ASCR is a foundation upon which many different types of therapies can be built. Several possibilities include the use of anti\u2010angiogenesis agents, monoclonal antibodies and biologic response modifiers.<\/jats:p>","DOI":"10.1111\/j.1398-2265.2004.00202.x","type":"journal-article","created":{"date-parts":[[2004,5,18]],"date-time":"2004-05-18T08:08:22Z","timestamp":1084867702000},"page":"28-32","source":"Crossref","is-referenced-by-count":29,"title":["Application of stem cell transplant for brain tumors"],"prefix":"10.1111","volume":"8","author":[{"given":"Sharon L.","family":"Gardner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,18]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950415)75:8<2186::AID-CNCR2820750825>3.0.CO;2-F"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500320053012"},{"key":"e_1_2_7_4_2","first-page":"736","article-title":"Phase I and pharmacokinetic evaluation of thiotepa in the cerebrospinal fluid and plasma of pediatric patients: evidence for dose\u2010dependent plasma clearance of thiotepa","volume":"49","author":"Heideman RL","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_7_5_2","first-page":"227","article-title":"High\u2010dose busulfan and thiotepa with autologous bone marrow transplantation in childhood malignant brain tumors: a phase II study","volume":"9","author":"Kalifa C","year":"1992","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.2.382"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.5.1814"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.222"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/415436a"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.10369"},{"issue":"2","key":"e_1_2_7_11_2","first-page":"s72","article-title":"High dose etoposide and thiotepa for refractory and recurrent malignant intracranial germ cell tumours (CNS GCT)","volume":"2","author":"Bouffet E","year":"2000","journal-title":"Neuro-oncol"},{"key":"e_1_2_7_12_2","volume-title":"High Dose Chemotherapy with Autologous Stem Cell Rescue in Patients with Recurrent CNS Germ Cell Tumors. Childhood Cancer into the 21st Century","author":"Modak S","year":"1997"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006395719917"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.9.2495"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00146088"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.7.2486"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.210"},{"key":"e_1_2_7_18_2","first-page":"245","article-title":"Newly diagnosed medulloblastoma with leptomeningeal dissemination in young children: response to \u2018\u2018Head Start\u2019\u2019 induction chemotherapy intensified with high dose methotrexate. Oral presentation, 34th Annual Congress of the International Society of Paediatric Oncology, Porto, Portugual, September 2002","volume":"39","author":"Chi S","year":"2002","journal-title":"Med Pediatr Oncol"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199403313301303"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306173282401"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950250109"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.6.1377"},{"key":"e_1_2_7_23_2","first-page":"526","article-title":"Chemotherapy in infants with malignant brain tumors","volume":"17","author":"Geyer R","year":"1998","journal-title":"Proc ASCO"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003810050277"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.10.2696"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200007000-00077"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-2265.2004.00202.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-2265.2004.00202.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T02:06:27Z","timestamp":1695780387000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-2265.2004.00202.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,18]]},"references-count":25,"journal-issue":{"issue":"s5","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1111\/j.1398-2265.2004.00202.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-2265.2004.00202.x","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,18]]}}}