{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:57Z","timestamp":1761058677843},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,4,28]],"date-time":"2007-04-28T00:00:00Z","timestamp":1177718400000},"content-version":"vor","delay-in-days":4592,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:p>The variation in skin prick test (SPT) results was evaluated clinically during terfenadine treatment in 39 adult patients with pollen rhinitis. A change in the perceived state of the patient as regards sensitization to a specific pollen allergen or atopic constitution was judged to be clinically important. A randomized, double\u2010blind, crossover design was used, comprising 2 weeks on terfenadine 120 mg once a day and 2 weeks on placebo. SPT for two pollen allergens and histamine (10mg\/ml) were evaluated at the start of the study and at the end of each period. When SPT was used as a discovery test and liberal definitions were applied, predictive values for a positive test were 100%. 1\u2010Sensitivity ranged between 10 and 54% with substantially lower values when a histamine wheal reaction was noted. The inhibitory effect of terfenadine was detectable 2 weeks after withdrawal as a reduction in the median of the mean diameter for the histamine\u2010induced wheal response of 1 mm (0\u20131.5). The data implied that a <jats:italic>positive<\/jats:italic> SPT is reliable when liberal definitions are adopted for sensitization and atopy; a <jats:italic>negative<\/jats:italic> SPT is presumably reliable when the measurement artifact is considered and the wheal reaction to histamine is detectable.<\/jats:p>","DOI":"10.1111\/j.1398-9995.1994.tb02090.x","type":"journal-article","created":{"date-parts":[[2007,5,14]],"date-time":"2007-05-14T00:10:08Z","timestamp":1179101408000},"page":"702-706","source":"Crossref","is-referenced-by-count":2,"title":["Reliability of skin prick tests during terfenadine treatment in adults with pollen rhinitis"],"prefix":"10.1111","volume":"49","author":[{"given":"M.","family":"Christensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Moelby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Svendsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"238","article-title":"Suggestions for biological quantitative testing and standardization of allergen extracts","volume":"29","author":"Aas K","year":"1974","journal-title":"Acta Allergol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1988.tb00932.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(87)80198-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365519209104635"},{"issue":"10","key":"e_1_2_1_6_2","article-title":"Skin tests used in type 1 allergy testing. 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The architecture of clinical research","author":"Feinstein AR.","year":"1985"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198512053132305"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1986.tb01979.x"},{"issue":"14","key":"e_1_2_1_10_2","first-page":"55","article-title":"Methods of skin testing","volume":"48","author":"Malling H\u2010J.","year":"1933","journal-title":"Allergy"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1988.tb00398.x"},{"key":"e_1_2_1_12_2","volume-title":"Statistics at square one","author":"Swinscow TDV.","year":"1983"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80216-7"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1989.tb04196.x"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.1994.tb02090.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.1994.tb02090.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T07:18:07Z","timestamp":1698131887000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.1994.tb02090.x"}},"subtitle":["A clinical study"],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["10.1111\/j.1398-9995.1994.tb02090.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.1994.tb02090.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10]]}}}