{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T05:41:34Z","timestamp":1698298894049},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,28]],"date-time":"2007-04-28T00:00:00Z","timestamp":1177718400000},"content-version":"vor","delay-in-days":4500,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>Pigeon serum (PS) is one of the most common causes of hypersensitivity pneumonitis (HP). PS\u2010induced HP was examined in a dog model. The dogs (<jats:italic>n<\/jats:italic>=6) were immunized by i. m. injections of PS, followed by insufflation with aerosolized PS, while all control dogs (<jats:italic>n<\/jats:italic>=3) received saline only. All animals insufflated with PS developed tachypnea 2\u20134 h after PS inhalation. After PS insufflation, a significant decrease in arterial oxygen tension (PaO<jats:sub>2<\/jats:sub>) was detected in sensitized dogs. No change in PaO<jats:sup>2<\/jats:sup> was detected in sensitized dogs after saline or in the controls after PS insufflation. In intradermal skin tests with PS antigen, a positive skin reaction was found in 3\/6 dogs in 30 min, and in 5\/6 dogs in 6 and 48 h after the PS injections. Sensitized dogs showed a significant increase in PS\u2010specific IgG in serum and lavage fluid (LF). In LF of sensitized dogs, an increase in the percentage of lymphocytes, eosinophils, and neutrophils was detected. Sensitized dogs developed chronic interstitial inflammation with lymphocytes, macrophages, plasma cells, and eosinophils in lungs. Granulomas with lymphocytes, histiocytes, and giant cells were detected in both the interstitium and the bronchiolar wall in the lungs of sensitized dogs. PaO<jats:sup>2<\/jats:sup> was lowest in dogs showing the most severe interstitial inflammation in the lungs. The results indicate that dogs can be successfully used in immunologic and physiologic studies of PS\u2010induced HP.<\/jats:p>","DOI":"10.1111\/j.1398-9995.1995.tb02486.x","type":"journal-article","created":{"date-parts":[[2007,5,14]],"date-time":"2007-05-14T00:10:09Z","timestamp":1179101409000},"page":"78-84","source":"Crossref","is-referenced-by-count":2,"title":["Pigeon\u2010serum\u2010induced hypersensitivity pneumonitis in the dog"],"prefix":"10.1111","volume":"50","author":[{"given":"K. E.","family":"Reijula1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. P.","family":"Kurup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S.","family":"Clifford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.L","family":"Coon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. N.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1982.tb03299.x"},{"key":"e_1_2_1_3_2","first-page":"337","article-title":"la\u2010like antigen on T\u2010cells and their subpopulations in pulmonary sarcoidosis and in hypersensitivity pneumonitis: analysis of bronchoalveolar and blood lymphocytes","volume":"131","author":"Costabel U","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8707(67)90013-5"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(84)90077-0"},{"key":"e_1_2_1_6_2","first-page":"33","article-title":"Hypersensitivity pneumonitis in the monkey","volume":"97","author":"Hensley GT","year":"1974","journal-title":"Arch Pathol"},{"key":"e_1_2_1_7_2","first-page":"142","article-title":"Experimental diffuse alveolar damage in baboons","volume":"126","author":"Johanson WG","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4049\/jimmunol.128.1.116","article-title":"Hypersensitivity pneumonitis in non\u2010human primates. I. Studies on the relationship of immunoregulation and disease activity","volume":"128","author":"Keller RH","year":"1982","journal-title":"J Immunol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0176-6724(86)80084-0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000235106"},{"key":"e_1_2_1_11_2","first-page":"797","article-title":"Carotid artery loop for repeated catheterization of the left ventricle in dogs","volume":"70","author":"Meier MA","year":"1971","journal-title":"Surgery"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1152\/jappl.1971.30.1.161","article-title":"Carotid artery loop method of blood pressure measurement in the dog","volume":"30","author":"O'Brien DO","year":"1971","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)90398-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-1281(85)80047-7"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(86)80077-2"},{"key":"e_1_2_1_16_2","first-page":"47","article-title":"Immune reactions in allergic alveolitis","volume":"4","author":"Salvaggio JE.","year":"1991","journal-title":"Eur Respir J"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.6.1582"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1011459"},{"key":"e_1_2_1_19_2","first-page":"271","article-title":"Extrinsic allergic bronchioloalveolitis: serology and biopsy findings","volume":"64","author":"Sutinen S","year":"1983","journal-title":"Eur J Respir Dis"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90907-4"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.1995.tb02486.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.1995.tb02486.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T21:43:17Z","timestamp":1698270197000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.1995.tb02486.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1111\/j.1398-9995.1995.tb02486.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.1995.tb02486.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}