{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:52:56Z","timestamp":1787698376005,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> There are few controlled studies on the effects of anti\u2010inflammatory treatment on airway inflammation in newly diagnosed childhood asthma.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Sixty children with newly diagnosed mild persistent asthma, 5\u201310\u2003years of age, and 17 healthy control subjects were studied. Asthmatic children were randomized into an open study with two treatment groups: (1) budesonide 400\u2003<jats:italic>\u03bc<\/jats:italic>g twice daily for 1\u2003month, 200\u2003<jats:italic>\u03bc<\/jats:italic>g twice daily for 5\u2003months and (2) disodium cromoglycate (DSCG) 10\u2003mg three\u2010times daily for 6\u2003months. All exacerbations were treated with budesonide 400\u2003<jats:italic>\u03bc<\/jats:italic>g twice daily for 2\u2003weeks. Symptoms and lung function were recorded throughout the study.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Sputum induction was safe and the overall success rate was 71%. This improved with age and decreased after treatment. At baseline, the asthmatic children had more eosinophils in blood (0.26 <jats:italic>vs<\/jats:italic> 0.18\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/l, <jats:italic>P<\/jats:italic>\u2003=\u20030.03) and sputum (1.1 <jats:italic>vs<\/jats:italic> 0.0 %, <jats:italic>P<\/jats:italic>\u2003=\u20030.0001) than the control subjects. The numbers of sputum eosinophils correlated with bronchial responsiveness (<jats:italic>R<\/jats:italic>\u2003=\u2003\u22120.58, <jats:italic>P<\/jats:italic>\u2003=\u20030.0002). Eosinophils were higher in children with atopic asthma than with nonatopic asthma (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001), and in children with a history wheezing than in children without wheezing (<jats:italic>P<\/jats:italic>\u2003=\u20030.02). Six months of budesonide treatment, but not of DSCG, improved lung function (<jats:italic>P<\/jats:italic>\u2003=\u20030.007), decreased symptoms (<jats:italic>P<\/jats:italic>\u2003=\u20030.007) and sputum eosinophils (<jats:italic>P<\/jats:italic>\u2003=\u20030.003). The effects of budesonide were pronounced in children with intense sputum eosinophilia (&gt;3%).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Sputum eosinophilia is present in children with newly diagnosed mild persistent asthma. Treatment with inhaled budesonide, but not with DSCG, decreases sputum eosinophils along with clinical and functional improvement.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2004.00504.x","type":"journal-article","created":{"date-parts":[[2004,7,2]],"date-time":"2004-07-02T06:36:03Z","timestamp":1088750163000},"page":"839-844","source":"Crossref","is-referenced-by-count":18,"title":["Induced sputum in children with newly diagnosed mild asthma: the effect of 6\u2003months of treatment with budesonide or disodium cromoglycate"],"prefix":"10.1111","volume":"59","author":[{"given":"P.","family":"Rytil\u00e4","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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