{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:01:21Z","timestamp":1778310081008,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Most studies show a steep increase in asthma prevalence in the last decades, although few studies had applied the same methodology. Recent reports point out the possibility that the epidemic has come to an end. We have studied the prevalence of asthma in a very large sample of children, repeating the study eight years apart.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Repeated cross\u2010sectional studies using the International Study of Asthma and Allergies in Childhood (ISAAC) protocol in a sample of Spanish schoolchildren 6\u20137 (parent\u2010reported) and 13\u201314 (self\u2010reported) years old in 1994\u201395 (phase I) and 2002\u20132003 (phase III). The number of participants was 42\u2003417 in phase I and 42\u2003813 in phase III. The participation rate was over 87% (13\u201314\u2003years) and 70% (6\u20137\u2003years).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The prevalence of wheezing in the previous year in children aged 13\u201314\u2003years was 9.0 and 9.3% for boys and 9.6 and 9.2% for girls for phases I and III, respectively. Children 6\u20137\u2003years of age showed a substantial increase in wheezing in the previous year (7.0 and 10.7% for boys and 5.3 and 8.2% for girls). Other symptoms and severity indexes followed the same patterns.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In the last 8\u2003years, the prevalence of asthma has not changed in 13\u201314\u2010year\u2010old Spanish children but has increased substantially in 6\u20137\u2010year olds.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2004.00562.x","type":"journal-article","created":{"date-parts":[[2004,10,26]],"date-time":"2004-10-26T12:03:42Z","timestamp":1098792222000},"page":"1301-1307","source":"Crossref","is-referenced-by-count":115,"title":["Stabilization of asthma prevalence among adolescents and increase among schoolchildren (ISAAC phases I and III) in Spain*"],"prefix":"10.1111","volume":"59","author":[{"given":"L.","family":"Garc\u00eda\u2010Marcos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Blanco","family":"Quir\u00f3s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Garc\u00eda","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Guill\u00e9n\u2010Grima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Gonz\u00e1lez","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. Carvajal","family":"Ure\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Arnedo","family":"Pena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Busquets","family":"Monge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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