{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:41:00Z","timestamp":1776897660673,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,11,16]],"date-time":"2004-11-16T00:00:00Z","timestamp":1100563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Heat\u2010killed <jats:italic>Listeria monocytogenes<\/jats:italic> (HKL) potently stimulates interferon (IFN)\u2010<jats:italic>\u03b3<\/jats:italic> production in CD4 T\u2010lymphocytes, and when used as adjuvant for immunotherapy, reduces immunoglobulin (Ig)E production and reverses established allergen\u2010induced airway hyperreactivity (AHR) in a murine model of asthma. We asked if such treatment could decrease established peanut\u2010induced anaphylaxis or cow's milk\u2010induced food allergy in highly food\u2010allergic dogs.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We therefore studied four 4\u2010year\u2010old atopic colony dogs extremely allergic to peanut (Group I), as well as five 7\u2010year\u2010old dogs very allergic to wheat, milk and other foods (Group II). All dogs experienced marked allergic symptoms, including vomiting and diarrhea on oral challenge with the relevant foods. The dogs were then vaccinated once subcutaneously with peanut or milk and wheat with HKL emulsified in incomplete Freund's adjuvant.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Following vaccination of the allergic dogs with HKL and allergen, oral challenges with peanut (Group I) or milk (Group II) elicited only minor or no symptoms. In addition, skin test end\u2010point titrations showed marked reductions for &gt;10\u2003weeks after treatment, and levels of Ara h 1\u2010specific IgE in serum of peanut sensitive dogs, as demonstrated by immunoblotting, were greatly reduced by treatment with HKL plus peanut allergen.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Thus, HKL plus allergen treatment markedly improved established food allergic responses in dogs, suggesting that such an immunotherapy strategy in humans might greatly improve individuals with food allergy and anaphylaxis.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2004.00711.x","type":"journal-article","created":{"date-parts":[[2005,8,2]],"date-time":"2005-08-02T05:19:49Z","timestamp":1122959989000},"page":"243-250","source":"Crossref","is-referenced-by-count":54,"title":["Allergen immunotherapy with heat\u2010killed <i>Listeria monocytogenes<\/i> alleviates peanut and food\u2010induced anaphylaxis in dogs"],"prefix":"10.1111","volume":"60","author":[{"given":"O. L.","family":"Frick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. S.","family":"Teuber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. B.","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Morigasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. T.","family":"Umetsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,16]]},"reference":[{"key":"e_1_2_23_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70224-1"},{"key":"e_1_2_23_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112031"},{"key":"e_1_2_23_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.6.3289"},{"key":"e_1_2_23_5_2","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.4049\/jimmunol.161.8.4146","article-title":"Heat killed Listeria monocytogenes as an adjuvant converts established Th2\u2010dominated immune responses into Th1\u2010dominated responses","volume":"161","author":"Yeung VP","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_23_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.1.223"},{"key":"e_1_2_23_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)80006-1"},{"key":"e_1_2_23_8_2","first-page":"40","article-title":"The atopic dog: a model for food allergy","volume":"47","author":"Ermel R","year":"1997","journal-title":"Lab Anim Sci"},{"key":"e_1_2_23_9_2","volume-title":"Guide for the care and use of laboratory animals","author":"Council NR","year":"1996"},{"key":"e_1_2_23_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.130056"},{"key":"e_1_2_23_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70029-1"},{"key":"e_1_2_23_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.107395"},{"key":"e_1_2_23_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/7385"},{"key":"e_1_2_23_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022613"},{"key":"e_1_2_23_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.4.2064"},{"key":"e_1_2_23_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/35074106"},{"key":"e_1_2_23_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5273.352"},{"key":"e_1_2_23_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/378088a0"},{"key":"e_1_2_23_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.12.6638-6645.2002"},{"key":"e_1_2_23_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.7.3863"},{"key":"e_1_2_23_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.5.1675"},{"key":"e_1_2_23_22_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"e_1_2_23_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2003.09.012"},{"key":"e_1_2_23_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1122"},{"key":"e_1_2_23_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.2.959"},{"key":"e_1_2_23_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200212000-00012"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2004.00711.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2004.00711.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T05:21:36Z","timestamp":1696915296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2004.00711.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,16]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["10.1111\/j.1398-9995.2004.00711.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2004.00711.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,16]]}}}