{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:06:35Z","timestamp":1770501995393,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T00:00:00Z","timestamp":1102032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>Early asthmatic responses (EAR) and late asthmatic responses (LAR) to allergen are induced by the local release of a series of bronchoconstrictor mediators, including leukotrienes and histamine. Both anti\u2010leukotrienes and other anti\u2010asthma drugs, such as inhaled glucocorticoids, have been shown to reduce both EAR and LAR. The aim of the present study was to directly compare the effects of regular treatment with an oral anti\u2010leukotriene, montelukast (Mont; 10\u2003mg once daily, for 8\u2003days), and an inhaled glucocorticoid [fluticasone propionate (FP) 250\u2003<jats:italic>\u03bc<\/jats:italic>g twice daily for 8\u2003days] on the EAR and LAR to an inhaled allergen challenge. Patients with a documented EAR and LAR at a screening visit were randomized to these treatments, or placebo, in a double\u2010blind, double\u2010dummy, crossover fashion. Allergen challenge at a dose causing both an EAR and LAR was given on the eighth day of treatment. The maximum fall in FEV<jats:sub>1<\/jats:sub> during the EAR was 17.8% during placebo treatment, 8.3% during Mont and 16.3% during FP (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05 for Mont <jats:italic>vs<\/jats:italic> placebo). The maximum fall during the EAR was 13.8% during placebo treatment, 11.8% during Mont and 2% during FP treatment (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05 for FP <jats:italic>vs<\/jats:italic> placebo and FP <jats:italic>vs<\/jats:italic> Mont). PC<jats:sub>20<\/jats:sub> methacholine was significantly higher 24\u2003h after allergen challenge during FP\u2010treatment compared with Mont (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Both montelukast and fluticasone reduced the relative amount of sputum eosinophils after allergen compared with placebo treatment. This study shows that anti\u2010leukotrienes are effective to attenuate the EAR, whereas inhaled glucocorticoids are more effective than anti\u2010leukotrienes in attenuating the EARs and improves bronchial hyperresponsiveness to a greater extent. In conclusion, inhaled glucocorticoids have overall greater efficacy than oral anti\u2010leukotrienes to attenuate allergen\u2010induced airway responses in mild asthmatic patients.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2005.00633.x","type":"journal-article","created":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T09:27:17Z","timestamp":1102066037000},"page":"65-70","source":"Crossref","is-referenced-by-count":30,"title":["Differential effects of fluticasone and montelukast on allergen\u2010induced asthma"],"prefix":"10.1111","volume":"60","author":[{"given":"M.","family":"Palmqvist","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sj\u00f6strand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Arvidsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"L\u00f6tvall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,3]]},"reference":[{"key":"e_1_2_18_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1977.tb01481.x"},{"key":"e_1_2_18_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(87)90204-1"},{"key":"e_1_2_18_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.2001120"},{"key":"e_1_2_18_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70083-1"},{"key":"e_1_2_18_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90277-V"},{"key":"e_1_2_18_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00447.x"},{"key":"e_1_2_18_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.6_Pt_1.1472"},{"key":"e_1_2_18_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.1.25"},{"key":"e_1_2_18_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.2.8756799"},{"key":"e_1_2_18_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70075-7"},{"key":"e_1_2_18_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9903097"},{"key":"e_1_2_18_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.5.419"},{"key":"e_1_2_18_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70246-5"},{"key":"e_1_2_18_15_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1155\/2000\/254213","article-title":"Protective effects of fluticasone on allergen\u2010induced airway responses and sputum inflammatory markers","volume":"7","author":"Parmeswaran K","year":"2000","journal-title":"Can Respir J"},{"key":"e_1_2_18_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14a04.x"},{"key":"e_1_2_18_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.6.9803042"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2005.00633.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2005.00633.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T02:45:35Z","timestamp":1697424335000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2005.00633.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,3]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1111\/j.1398-9995.2005.00633.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2005.00633.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,3]]}}}