{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T03:15:43Z","timestamp":1794539743616,"version":"4.9.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T00:00:00Z","timestamp":1102032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    Mustard IgE\u2010mediated allergy is supposed to be a rare cause of food allergy, and its clinical features and cross\u2010reactivities have not been fully elucidated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    A prospective study was carried out, recruiting mustard allergic patients, and paired control subjects. A clinical questionnaire was administered, and skin\u2010prick tests (SPT) with panels of aeroallergens and foods, serum extraction for\n                    <jats:italic>in vitro<\/jats:italic>\n                    tests and double\u2010blind placebo\u2010controlled food challenges (DBPCFC) were performed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Thirty\u2010eight mainly adult patients, with 10.5% reporting systemic anaphylaxis, were included in the study [age (mean\u2003\u00b1\u2003SD): 21.9\u2003\u00b1\u20038.6\u2003years]. DBPCFC were performed in 24 patients, being positive in 14 cases (58.3%). Patients with positive outcome showed significantly greater mustard SPT than those with negative outcome (8.2\u2003\u00b1\u20033.7\n                    <jats:italic>vs<\/jats:italic>\n                    5.3\u2003\u00b1\u20032.4\u2003mm,\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&lt;\u20030.05), and the receiver\u2010operating characteristic (ROC) curve analysis yielded a cut\u2010off value for mustard commercial SPT of 8\u2003mm, with a specificity of 90% (95% CI, 55.5\u201398.3), and a sensitivity of 50% (95% CI, 23.1\u201376.9). A significant association between mustard hypersensitivity and mugwort pollen sensitization was found (97.4% of patients), with partial cross\u2010reactivity demonstrated by UniCAP System inhibition assays. All patients showed sensitization to other members of Brassicaceae family, and cross\u2010reactivity among them was also confirmed. Moreover, significant associations with nut (97.4%), leguminous (94.7%), corn (78.9%), and Rosaceae fruit (89.5%) sensitizations were also shown. Around 40% of these food sensitizations were symptomatic, including food\u2010dependent exercise\u2010induced anaphylaxis in six patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    Mustard allergy is a not\u2010uncommon disorder that can induce severe reactions. Significant associations with mugwort pollinosis and several plant\u2010derived food allergies are demonstrated, suggesting a new mustard\u2013mugwort allergy syndrome. A relationship between this syndrome and food\u2010dependent exercise\u2010induced anaphylaxis is also reported.\n                  <\/jats:p>","DOI":"10.1111\/j.1398-9995.2005.00644.x","type":"journal-article","created":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T04:27:17Z","timestamp":1102048037000},"page":"48-55","source":"Crossref","is-referenced-by-count":91,"title":["Mustard allergy confirmed by double\u2010blind placebo\u2010controlled food challenges: clinical features and cross\u2010reactivity with mugwort pollen and plant\u2010derived foods"],"prefix":"10.1111","volume":"60","author":[{"given":"J.","family":"Figueroa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G.","family":"Dumpi\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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