{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:57:29Z","timestamp":1793829449601,"version":"4.6.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T00:00:00Z","timestamp":1106870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    The clinical characteristics in olive pollen allergy are dependent on the antigenic load, the allergens profile, and the genetic restrictions. Our objective was to determine specific response pattern in Ole e 2 and Ole e 10 sensitization at those levels.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    We studied 146 patients with seasonal rhinitis and\/or asthma and positive prick test to\n                    <jats:italic>Olea europaea<\/jats:italic>\n                    pollen. IgE against Ole e 2 and Ole e 10 were detected by skin prick test and ELISA. HLA\u2010DRB1 and HLA\u2010DQB1 loci were typed by polymerase chain reaction sequence\u2010specific primers method.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    A total of 102 (69.9%) and 79 (54.0%) patients showed significant IgE antibody response against Ole e 2 and Ole e 10, respectively. There was a significant association between Ole e 2 (OR 2.2,\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.04) and Ole e 10 reactivities (OR 2.8,\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.007) with asthma. In addition, total and specific IgE antibody levels significantly correlated with asthma (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&lt;\u20030.05). Patients who reacted to both allergens reached the highest asthma risk factor (OR 4.3,\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.002). Phenotypic frequency of DR7 (OR 5.4,\n                    <jats:italic>Pc<\/jats:italic>\n                    \u2003=\u20030.003) and DQ2 (OR 3.6,\n                    <jats:italic>Pc<\/jats:italic>\n                    \u2003=\u20030.02) were increased in positive Ole e 2 patients compared with control subjects. DR2(15) phenotypic frequency was significantly increased (OR 5.6,\n                    <jats:italic>Pc<\/jats:italic>\n                    \u2003=\u20030.02) in positive Ole e 10 patients compared with control subjects.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    Our data suggest an association of Ole e 2 and Ole e 10 with bronchial asthma. Also, we found a genetic control of Ole e 2 and Ole e 10 IgE\u2010specific responses that could be relevant to clinical disease in olive pollen allergy.\n                  <\/jats:p>","DOI":"10.1111\/j.1398-9995.2005.00698.x","type":"journal-article","created":{"date-parts":[[2005,1,29]],"date-time":"2005-01-29T05:01:29Z","timestamp":1106974889000},"page":"360-365","source":"Crossref","is-referenced-by-count":24,"title":["Ole e 2 and Ole e 10: new clinical aspects and genetic restrictions in olive pollen allergy"],"prefix":"10.1111","volume":"60","author":[{"given":"J.","family":"Quiralte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Llanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Barral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Arias de Saavedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"S\u00e1enz de San Pedro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Villalba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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