{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:18:56Z","timestamp":1697001536549},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T00:00:00Z","timestamp":1106870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> A type 2 immune response, characterized by high levels of interleukin\u20104 and immunoglobulin E synthesis is a hallmark of respiratory allergic diseases. Individuals infected with human T\u2010lymphotropic virus type I (HTLV\u2010I) virus have spontaneous T\u2010cell proliferation and increased interferon <jats:italic>\u03b3<\/jats:italic> production, which are immunological functions associated with a type 1 immune response.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To determine the frequency of asthma and rhinitis symptoms and immediate skin reactivity to aeroallergens in HTLV\u2010I infected individuals, compared with noninfected subjects.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Cross sectional study of 101 HTLV\u2010I infected and 101 control uninfected blood donors, assessed by enzyme\u2010linked immunosorbent assay and Western blot assays. The subjects were age and sex\u2010matched, identified as presenting allergy history by questionnaire, which was complemented by a complete clinical examination and skin prick tests for aeroallergens.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The frequency of atopy was lower in infected than uninfected subjects, 14.9 and 29.7% (<jats:italic>P<\/jats:italic>\u2003=\u20030.017), respectively. Skin reactivity to <jats:italic>Dermatophagoides pteronissynus<\/jats:italic>, <jats:italic>Dermatophagoides farinae<\/jats:italic> and <jats:italic>Blomia tropicalis<\/jats:italic> were the most frequently observed among all the tested antigens in both groups. Skin reactivity to histamine was also reduced in the infected individuals compared with uninfected subjects (medians 4.0 <jats:italic>vs<\/jats:italic> 5.0, respectively; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). Infection by HTLV\u2010I was found to be a factor of protection to atopy (RP 0.44; <jats:italic>P<\/jats:italic>\u2003=\u20030.005).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The HTLV\u2010I infection reduces the frequency of respiratory allergy and skin reactivity to aeroallergens.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2005.00709.x","type":"journal-article","created":{"date-parts":[[2005,1,29]],"date-time":"2005-01-29T10:01:29Z","timestamp":1106992889000},"page":"379-384","source":"Crossref","is-referenced-by-count":4,"title":["Skin reactivity to aeroallergens is reduced in human T\u2010lymphotropic virus type I\u2010infected healthy blood\u2010donors (asymptomatic carriers)"],"prefix":"10.1111","volume":"60","author":[{"given":"A.","family":"Souza\u2010Machado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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