{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:46:54Z","timestamp":1791193614034,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,4,6]],"date-time":"2005-04-06T00:00:00Z","timestamp":1112745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The development of animal models developing specific immunoglobulin (Ig)E presenting the same specificity as human IgE and similar clinical symptoms as those observed in allergic patients are of great interest for the understanding of mechanisms involved in the induction and regulation of food allergy.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Balb\/c female mice were sensitized with whole peanut protein extract (WPPE) by means of intraperitoneal (i.p.) injections with alum or gavages with cholera toxin (CT). The WPPE specific IgE, IgG1 and IgG2a were monitored. Th2 cells activation was analysed assaying interleukin (IL)\u20104 and IL\u20105 <jats:italic>vs<\/jats:italic> IFN<jats:italic>\u03b3<\/jats:italic> on reactivated splenocytes. Local anaphylactic reaction was evaluated by assaying histamine in faecal samples. The oral sensitization protocol was further extended to cow's milk proteins (CMP).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Balb\/c mice developed high peanut\u2010specific IgE and IgG1 responses either after i.p. or oral sensitizations. In both cases, antibodies were specific to polymer of glycinin fragments, containing polypeptides from Ara h3\/4, and to a lesser extent to Ara h1 and Ara h2. Interleukin\u20104 and IL\u20105 production were evidenced. Balb\/c mice could also be sensitized to CMP, as demonstrated by CMP\u2010specific IL\u20104 and IL\u20105 secretions and induction of IgE specific for whole caseins, <jats:italic>\u03b2<\/jats:italic>\u2010lactoglobulin, serum bovine albumin and lactoferrin. Of interest was the occurrence of a local anaphylactic reaction in the peanut and CM models.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> In contrast with previous authors, Balb\/c mice were sensitized and evidenced an allergic reaction after oral administrations of peanut or CMP plus CT, providing an interesting model for further studies on immunopathogenic mechanisms.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2005.00767.x","type":"journal-article","created":{"date-parts":[[2005,4,6]],"date-time":"2005-04-06T15:05:26Z","timestamp":1112799926000},"page":"658-664","source":"Crossref","is-referenced-by-count":93,"title":["Peanut\u2010 and cow's milk\u2010specific IgE, Th2 cells and local anaphylactic reaction are induced in Balb\/c mice orally sensitized with cholera toxin"],"prefix":"10.1111","volume":"60","author":[{"given":"K.","family":"Adel\u2010Patient","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ah\u2010Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cr\u00e9minon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010M.","family":"Wal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,6]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"European Commission Report T72.Scientific co\u2010operation on questions relating to food: consideration of the epidemiological basis for appropriate measures for the protection of public health in respect to food allergy. 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