{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:57:56Z","timestamp":1772837876145,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T00:00:00Z","timestamp":1119312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p>Immunoglobulin E (IgE) was the last of the immunoglobulins discovered. It is present in very low amounts (nano\u2010 to micro\u2010gram per ml range) in the serum of normal healthy individuals and normal laboratory mouse strains and has a very short half\u2010life. This contrasts with the other immunoglobulin classes, which are present in much higher concentrations (micro\u2010 to milligram per ml range) and form a substantial component of serum proteins. Immunoglobulins play a role in homeostatic mechanisms and they represent the humoral arm of defence against pathogenic organisms. Since IgE antibodies play a key role in allergic disorders, a number of approaches to inhibit IgE antibody production are currently being explored. In the recent past the use of nonanaphylactic, humanized anti\u2010IgE antibodies became a new therapeutic strategy for allergic diseases. The therapeutic rational beyond the idea derives from the ability of the anti\u2010IgE antibodies to bind to the same domains on the IgE molecule that interact with the high\u2010affinity IgE receptor, thereby interfering with the binding of IgE to this receptor without cross\u2010linking the IgE on the receptor (nonanaphylactic anti\u2010IgE antibodies). Treatment with anti\u2010IgE antibodies leads primarily to a decrease in serum IgE levels. As a consequence thereof, the number of high\u2010affinity IgE receptors on mast cells and basophils decreases, leading to a lower excitability of the effector cells reducing the release of inflammatory mediator such as histamine, prostaglandins and leukotrienes. Experimental studies in mice indicate that injection of some monoclonal anti\u2010IgE antibodies also inhibited IgE production <jats:italic>in vivo<\/jats:italic>. The biological mechanism behind this reduction remains speculative. A possible explanation may be that these antibodies can also interact with membrane bound IgE on B cells, which could interfere the IgE production.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2005.00832.x","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T17:02:09Z","timestamp":1119373329000},"page":"977-985","source":"Crossref","is-referenced-by-count":28,"title":["Molecular and cellular targets of anti\u2010IgE antibodies"],"prefix":"10.1111","volume":"60","author":[{"given":"D.","family":"Inf\u00fchr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Crameri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Lamers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Achatz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,21]]},"reference":[{"key":"e_1_2_12_2_2","first-page":"840","article-title":"Physicochemical properties of reaginic antibody. 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