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Food allergy encompasses a whole spectrum of disorders, with symptoms that may be cutaneous, gastrointestinal or respiratory in nature. Food disorders also differ according to the extent that they are immunoglobulin E (IgE)\u2010mediated. Skin\u2010prick testing is often used to identify food sensitization, although double\u2010blind, placebo\u2010controlled food challenge (DBPCFC) tests remain the gold standard for diagnosis. Recent evidence suggests that quantitative IgE measurements can predict the outcome of DBPCFC tests and can replace about half of all oral food challenges. When an extensive medical history is obtained in combination with IgE quantification, even fewer patients may require formal food challenges. It has also become possible to map the IgE\u2010binding regions of many major food allergens. This may help to identify children with persistent food allergy, as opposed to those who may develop clinical tolerance. In future, microarray technology may enable physicians to screen patients for a large number of food proteins and epitopes, using just a few drops of blood.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2005.00853.x","type":"journal-article","created":{"date-parts":[[2005,4,12]],"date-time":"2005-04-12T12:31:08Z","timestamp":1113309068000},"page":"19-24","source":"Crossref","is-referenced-by-count":146,"title":["Food allergy \u2013 accurately identifying clinical reactivity"],"prefix":"10.1111","volume":"60","author":[{"given":"H. 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