{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:28:09Z","timestamp":1789943289801,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,8,2]],"date-time":"2005-08-02T00:00:00Z","timestamp":1122940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> A randomized double\u2010blind, placebo\u2010controlled study was conducted in patients allergic asthma sensitized to <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To evaluate the efficacy and safety after 1\u2010year of immunotherapy with a modified <jats:italic>D. pteronyssinus<\/jats:italic> extract compared with placebo.<\/jats:p><jats:p><jats:bold>Material and methods:\u2002<\/jats:bold> Fifty\u2010five patients were randomly allocated to receive the active treatment (<jats:italic>n<\/jats:italic>\u2003=\u200329), or placebo (<jats:italic>n<\/jats:italic>\u2003=\u200326). The main outcome was the specific bronchial provocation test (BPT). Other parameters analysed were dose\u2013response skin prick test (SPT), symptom and medication scores and asthma quality of life (AQLQ).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> At the end of the study, the active group showed a significant increase in the PD<jats:sub>20<\/jats:sub>FEV<jats:sub>1<\/jats:sub> compared with placebo (<jats:italic>P<\/jats:italic>\u2003=\u20030.0029). Nineteen patients of the active <jats:italic>vs<\/jats:italic> 10 of the placebo group needed more than twice the initial amount of allergen extract to have a positive BPT (<jats:italic>P<\/jats:italic>\u2003=\u20030.0293); seven patients in the placebo <jats:italic>vs<\/jats:italic> one in the active group needed less than half (<jats:italic>P<\/jats:italic>\u2003=\u20030.0137). In SPT, a significant improvement (<jats:italic>P<\/jats:italic>\u2003=\u20030.0049) was found in the active group. This group also had a median reduction of 91.5% in symptom scores, whereas the placebo group increased by 86%. Medication scores decreased in both groups (56% in the active and 11.4% in the placebo). In AQLQ, the differences between both groups were significant (<jats:italic>P<\/jats:italic>\u2003=\u20030.0234) at the end of the study.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> After 1\u2003year of treatment, the modified extract of <jats:italic>D. pteronyssinus<\/jats:italic> demonstrated to be safe and efficacious to treat patients with asthma and allergic rhinoconjunctivitis sensitized to this mite.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2005.00862.x","type":"journal-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T06:04:36Z","timestamp":1123049076000},"page":"1178-1183","source":"Crossref","is-referenced-by-count":69,"title":["Double\u2010blind and placebo\u2010controlled study to assess efficacy and safety of a modified allergen extract of <i>Dermatophagoides pteronyssinus<\/i> in allergic asthma"],"prefix":"10.1111","volume":"60","author":[{"given":"A.","family":"Ameal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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