{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:25:42Z","timestamp":1758709542842},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T00:00:00Z","timestamp":1124150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> High concentrations of nitric oxide (NO) originating from a type\u20102 nitric oxide synthase (NOS2) located within the paranasal sinuses are measured in nasal air in man. NO is believed to play a central role in nonspecific defense of paranasal sinuses. Glucocorticoids (GCs), a therapeutic often used for a wide range of diseases, is known to strongly downregulate NOS2.<\/jats:p><jats:p><jats:bold>Aims of the study:\u2002<\/jats:bold> To investigate the effect of very high intravenous doses of GCs on nasal NO in man.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Nasal NO was measured in 15 patients without any history of allergy or chronic airway disorder who were treated for 3\u2003days with a daily dose of 1000\u2003mg methylprednisolone for an exacerbation of multiple sclerosis. Nasal NO was also measured in 30 matched control subjects.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In control subjects, the maximal value of nasal NO [mean (SE)] was 233 (8)\u2003part per billion (ppb), and did not differ from patients with multiple sclerosis [maximum value: 219 (13)\u2003ppb; left nostril: 214 (12)\u2003ppb; right nostril: 215\u2003(12) ppb]. After GCs treatment, nasal NO increased in patients [maximum value: 250 (13)\u2003ppb (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001); left nostril: 249 (12)\u2003ppb (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001); right nostril: 244 (13)\u2003ppb (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001)].<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> We conclude that GCs do not decrease but even increase nasal NO.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2005.00880.x","type":"journal-article","created":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T15:58:08Z","timestamp":1125503888000},"page":"1323-1326","source":"Crossref","is-referenced-by-count":4,"title":["Nasal nitric oxide, the guardian of paranasal sinuses, is paradoxically increased by high doses of intravenous glucocorticoids"],"prefix":"10.1111","volume":"60","author":[{"given":"B.","family":"Degano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"T\u00eatu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Didier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. \u2010F.","family":"Arnal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.82"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.53.082901.103909"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.1.255"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.8841"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0495-370"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200207-640OC"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.2.405"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13b15.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09071344"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00635.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.1.2002125"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200405000-00027"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01379.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200202-138BC"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106639200"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00172-0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430317"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.10043"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2005.00880.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2005.00880.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T11:01:13Z","timestamp":1697454073000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2005.00880.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,31]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1111\/j.1398-9995.2005.00880.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2005.00880.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,31]]}}}