{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:53:03Z","timestamp":1767905583993,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T00:00:00Z","timestamp":1128297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Severe anaphylactic reactions are medical emergencies requiring immediate recognition and treatment. Despite this, little is known on their clinical features, especially in infants and children.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To evaluate trigger factors, patterns of clinical reaction, site of occurrence and treatment modalities of reported reaction in infants and children below 12\u2003years of age in Germany.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Paediatricians throughout Germany were asked by questionnaire to report accidental anaphylactic reactions over the previous 12\u2003months. Severity of reported reactions was classified in grades I\u2013IV according to reported symptoms.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Hundred and three cases of anaphylaxis were evaluated. Median age was 5\u2003years, 58% were boys. Site of occurrence was the child's home in the majority of cases (58%). Foods were the most common causative allergen (57%), followed by insect stings (13%) and immunotherapy (SIT) (12%); in 8% anaphylactic agent was unknown. Among foods, peanuts and tree nuts were the most frequent allergens (20% of food allergens in each case). Severe reactions with cardiovascular involvement occurred in 24% of cases. No fatal reaction was observed. Recurrent episodes of anaphylaxis were reported in 27% of cases, half of these caused by the same allergen again. For treatment, 20% of children received adrenaline, in 8% of cases intravenously. Thirty\u2010six per cent of patients with grade\u2010IV reactions received adrenaline, 24% intravenously. In 17% of all children an adrenaline self\u2010injector was prescribed after the episode.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Our data: (i) shows an uncertainty of physicians in diagnosing anaphylaxis, (ii) reveals remarkable under\u2010treatment of the majority of children with anaphylaxis, (iii) reflects the need for guidelines and training for physicians in managing children with anaphylaxis and (iv) should encourage the development of self\u2010management programmes for patients and families.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2005.00909.x","type":"journal-article","created":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T09:09:21Z","timestamp":1128330561000},"page":"1440-1445","source":"Crossref","is-referenced-by-count":165,"title":["Anaphylactic reactions in children \u2013 a questionnaire\u2010based survey in Germany"],"prefix":"10.1111","volume":"60","author":[{"given":"A.","family":"Mehl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Wahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Niggemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,3]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00864.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.4.273"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000136762.89313.0b"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112031"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.86.4.236"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199208063270603"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00785.x"},{"issue":"1","key":"e_1_2_8_9_2","article-title":"Anaphylaxis 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