{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:52:25Z","timestamp":1793364745700,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T00:00:00Z","timestamp":1137974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p><jats:bold>Background and aims:\u2002<\/jats:bold> Epidemiological evidence examining the role of atopy and\/or allergy in the pathogenesis of otitis media with effusion (OME) is inconclusive. The aim of this study was to assess any increased risk for OME attributable to allergy\u2010related factors, in a well\u2010characterized population using a case\u2010control design and multivariate analysis.<\/jats:p><jats:p><jats:bold>Subjects and methods:\u2002<\/jats:bold> Eighty\u2010eight 1\u20137\u2010year\u2010old children with OME, diagnosed by clinical and tympanometric evaluation and 80 matched controls were enrolled. A standardized questionnaire was completed, in order to assess factors related to OME and allergy\u2010related symptoms and diagnoses using strict clinical definitions. Specific IgE was measured by skin\u2010prick tests and\/or CAP\u2010FEIA.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The patient and control groups were well matched. Factors conferring increased risk for OME in the univariate analysis included IgE sensitization, dyspnea, wheezing, asthma, paroxysmal sneezing, rhinitis, eczema, \u2018any allergic disease,\u2019 family history of otitis media, and family history of allergy. After multivariate analysis IgE sensitization, wheezing, nasal obstruction, family history of otitis, and child\u2010care attendance remained as independent risk factors for development of OME.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> IgE sensitization and respiratory allergy symptoms are independent risk factors for the development of OME, suggesting that both immunological and mechanical pathways may contribute to the development of the disease. Otitis heritability provides additional risk, as well as frequent exposure to viral upper respiratory tract infections in children attending daycare. Treatment and\/or prevention of OME using anti\u2010allergic medications should be further examined.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2006.00971.x","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T18:07:38Z","timestamp":1138039658000},"page":"332-336","source":"Crossref","is-referenced-by-count":62,"title":["IgE sensitization, respiratory allergy symptoms, and heritability independently increase the risk of otitis media with effusion"],"prefix":"10.1111","volume":"61","author":[{"given":"F. M.","family":"Chantzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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