{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:03:53Z","timestamp":1759730633102},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,15]],"date-time":"2006-06-15T00:00:00Z","timestamp":1150329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Co\u2010vaccination with cellular pertussis vaccine down\u2010regulates allergic sensitization to diphtheria and tetanus antigens. Using a murine model, we investigated whether vaccination with diphtheria\/tetanus toxoids, administered separately or simultaneously with the whole cell vaccine of <jats:italic>Bordetella pertussis<\/jats:italic>, inhibits subsequent allergen\u2010induced immune and inflammatory responses.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> BALB\/c\u2010mice were vaccinated intracutaneously with a combination of diphtheria and tetanus toxoids or a combination of diphtheria and tetanus toxoids with a whole cell vaccine of <jats:italic>B. pertussis<\/jats:italic> (three times, days \u221221 to \u22127) prior to systemic sensitization (days 1\u201314) and repeated airway challenges (days 28\u201330) with ovalbumin.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Compared with negative controls, systemic sensitization and airway allergen challenges induced high serum levels of allergen\u2010specific IgE, predominant Th2\u2010type cytokine production, airway inflammation and development of <jats:italic>in vivo<\/jats:italic> airway hyperreactivity. Vaccination with diphtheria and tetanus toxoids prior to sensitization suppressed IgE formation and development of eosinophilic airway inflammation. Co\u2010vaccination with a whole cell pertussis vaccine inhibited allergen sensitization, airway inflammation and development of <jats:italic>in vivo<\/jats:italic> airway hyperreactivity. Prevention was due to an allergen\u2010specific and general shift from a predominant Th2 towards a predominant Th1 immune response.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Vaccination with diphtheria and tetanus toxoids alone or in combination with whole cell pertussis vaccine prior to allergen sensitization prevented allergen\u2010induced Th2 immune responses. Vaccine antigens may down\u2010regulate allergic responses to a range of common allergens.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2006.01093.x","type":"journal-article","created":{"date-parts":[[2006,6,15]],"date-time":"2006-06-15T15:07:31Z","timestamp":1150384051000},"page":"820-827","source":"Crossref","is-referenced-by-count":8,"title":["Common vaccine antigens inhibit allergen\u2010induced sensitization and airway hyperresponsiveness in a murine model"],"prefix":"10.1111","volume":"61","author":[{"given":"C.","family":"Gr\u00fcber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Gerhold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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