{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:24:58Z","timestamp":1775078698003,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T00:00:00Z","timestamp":1154563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Lentils are the most common legume involved in allergic reactions in the Mediterranean area and India. Lentil crops could be attacked by a wide range of insect species. Occupational asthma caused by the lentil pest <jats:italic>Bruchus lentis<\/jats:italic> has been described in the present study.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> We studied the possibility of immunoglobulin (Ig)E\u2010mediated hypersensitivity to lentil pests in 16 patients who suffered from allergic symptoms (asthma and anaphylaxis) related to inhalation of lentil particles or ingestion of lentils, in which sensitization to legume proteins was not clear.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Extracts prepared either from noninfested and infested lentils, and from the lentil parasite <jats:italic>B. lentis<\/jats:italic> were used for skin prick testing (SPT), bronchial and oral challenges and <jats:italic>in vitro<\/jats:italic> determinations.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Skin prick test were positive to infested lentils and <jats:italic>B. lentis<\/jats:italic> in all patients and negative to noninfested lentil extracts. Five asthmatic patients reacted in the bronchial challenge test with <jats:italic>Bruchus<\/jats:italic> extract. Oral challenges performed with boiled infested lentils were positive in six of seven patients. Immunoglobulin E immunoblotting with <jats:italic>Bruchus<\/jats:italic> and infested lentils extracts revealed protein bands that were reactive to serum IgE from six and four, respectively, out of 16 patients. These patients had no IgE to lentil\u2010specific proteins as determined by immunoblotting and Len c 1\u2010specific IgE test.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Lentil pest proteins can be a cause of IgE\u2010mediated rhinoconjunctivitis and asthma in patients eating or inhaling infested lentil particles.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2006.01123.x","type":"journal-article","created":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T14:53:27Z","timestamp":1154616807000},"page":"1112-1116","source":"Crossref","is-referenced-by-count":22,"title":["Allergic hypersensitivity to the lentil pest <i>Bruchus lentis<\/i>"],"prefix":"10.1111","volume":"61","author":[{"given":"A.","family":"Armentia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lombardero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"S\u00e1nchez\u2010Monge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,3]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70539-7"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1992.tb00962.x"},{"key":"e_1_2_5_4_2","first-page":"955","article-title":"Variaci\u00f3n estacional de los principales grupos de insectos de plaga y enemigos naturales asociados al cultivo de la lenteja (Lens culinaris medikus) en Castilla La Mancha","volume":"24","author":"P\u00e9rez G","year":"1998","journal-title":"Bol Sanid Veg, Plagas"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00293.x"},{"key":"e_1_2_5_6_2","unstructured":"Bruchidae collection of SZMN. Novosibirsk.Bruchus lentisFrolich 1799 RUBruchus pisorum(Linnaeus 1758) WSBruchus emarginatusAllard 1868 UkraineBruchus affinisFrolich 1799 RU WS. [http:\/\/www.szmn.sbras.ru\/Coleop\/Bruchid.htm] Accessed March 2006."},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-120026067"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1398-9995.2005.00828.x","article-title":"Controlled oral food challenges in children\u2010when indicated, when superfluous","volume":"60","author":"Niggeman B","year":"2005","journal-title":"Allergy"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2003.04.1399"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.08.035"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.06.010"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.109912"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1996.tb03883.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62299-5"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00299.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70539-7"},{"key":"e_1_2_5_18_2","first-page":"176","article-title":"Interaction of allergens from house\u2010dust mite and from cereal flours: Dermatophagoides pteronyssinus alpha\u2010amylase (Der p4) and wheat and rye alpha\u2010amylase inhibitors","volume":"51","author":"Sanchez\u2010Monge R","year":"1996","journal-title":"Allergy"},{"key":"e_1_2_5_19_2","first-page":"141","volume-title":"Plant food allergens","author":"Clare Mills EN","year":"2004"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2006.01123.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2006.01123.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T18:13:02Z","timestamp":1696961582000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2006.01123.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,3]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1111\/j.1398-9995.2006.01123.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2006.01123.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,3]]}}}