{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:25:04Z","timestamp":1791174304851,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T00:00:00Z","timestamp":1154476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2006,11]]},"abstract":"\n Background:\u2002<\/jats:bold>\n Based on the presence of nasal polyps on endoscopy, chronic rhinosinusitis (CRS) may be clinically divided in CRS with nasal polyps and CRS without nasal polyps. It is unclear, whether CRS with nasal polyps and CRS without nasal polyps represent different disease entities or just different stages of one single disease. In case of one disease, only minor histopathological differences between CRS with small early\u2010stage polyps (CRSNP\n (+)<\/jats:sup>\n ) and CRS without nasal polyps (CRSNP\n \u2212<\/jats:sup>\n ) were expected.\n <\/jats:p>\n \n Methods:\u2002<\/jats:bold>\n Patients with CRSNP\n (+)<\/jats:sup>\n confined to the infundibular region or CRSNP\n \u2212<\/jats:sup>\n were selected. Histochemical and immunohistochemical characterization of ethmoidal mucosa was performed on formalin\u2010fixed and paraffin\u2010embedded tissue specimens. Frequency and distribution of eosinophils, neutrophils, mast cells, IgE\n +<\/jats:sup>\n cells, macrophages, B\u2010 and T\u2010cell subsets, natural killer cells, plasma cells and goblet cells were assessed. In addition, the thickness of the basal membrane was evaluated.\n <\/jats:p>\n \n Results:\u2002<\/jats:bold>\n Nine CRS patients without detectable polyps, and 11 patients with small early\u2010stage polyps confined to the infundibular region were selected. Despite adjacent polyp stage, the amount of round cell infiltration (\n P<\/jats:italic>\n \u2003<\u20030.05), number of eosinophils (\n P<\/jats:italic>\n \u2003<\u20030.05), and plasma cells (\n P<\/jats:italic>\n \u2003<\u20030.01) significantly differed in the ethmoidal specimens from patients of the two groups.\n <\/jats:p>\n \n Conclusion:\u2002<\/jats:bold>\n Substantial histopathological differences were observed in ethmoidal mucosa of CRSNP\n (+)<\/jats:sup>\n and CRSNP\n \u2212<\/jats:sup>\n patients. Thus, the results of this investigation support the concept that CRS with nasal polyps and CRS without nasal polyps are two different disease entities rather than different stages of one single disease, but may also be interpreted as a higher degree of inflammation.\n <\/jats:p>","DOI":"10.1111\/j.1398-9995.2006.01132.x","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T18:04:28Z","timestamp":1154541868000},"page":"1275-1279","source":"Crossref","is-referenced-by-count":125,"title":["Distinct features of chronic rhinosinusitis with and without nasal polyps"],"prefix":"10.1111","volume":"61","author":[{"given":"D.","family":"Polzehl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Moeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Riechelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Perner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,27]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps","volume":"43","author":"Fokkens W","year":"2005","journal-title":"Rhinology"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.6.657"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0307-7772.2001.00525.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489709113422"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200204000-00026"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(99)00038-3"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.2500\/105065800781329573"},{"key":"e_1_2_5_10_2","volume-title":"Essentials of functional endoscopic sinus surgery","author":"Stammberger H","year":"1993"},{"key":"e_1_2_5_11_2","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1398-9995.1993.tb04756.x","article-title":"Allergen standardization and skin tests. 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Position paper","volume":"48","author":"Dreborg S","year":"1993","journal-title":"Allergy"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1487"},{"key":"e_1_2_5_14_2","first-page":"222","article-title":"\u2018\u2018Sniffin\u2019 sticks\u2019\u2019: screening of olfactory performance","volume":"34","author":"Kobal G","year":"1996","journal-title":"Rhinology"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400813"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70218-5"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-003-0043-4"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00364.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.2500\/108854196778662264"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-240OC"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-002-0088-9"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.12.022"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2006.01132.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2006.01132.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T12:19:23Z","timestamp":1696940363000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2006.01132.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,27]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1398-9995.2006.01132.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2006.01132.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,27]]}}}